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Search: Posts Made By: Nguyen
Forum: Articles of Interest Yesterday, 09:31 AM
Replies: 0
Views: 11
Posted By Nguyen
Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profilin

Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD‐L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer
...
Forum: Articles of Interest Yesterday, 09:30 AM
Replies: 0
Views: 8
Posted By Nguyen
Circulating tumour DNA analysis to direct therapy in advanced breast cancer

I have been waiting for significant data on this subject (“liquid biopsy”) for 2 decades now. Even with many tumor sites, it’s always risky to get my wife biopsy. Due to tumor heterogeneity one can...
Forum: Articles of Interest 09-17-2020, 04:43 PM
Replies: 0
Views: 29
Posted By Nguyen
“…evaluating palbociclib (CDK4/6) treatment outcome …”

https://www.biospace.com/article/releases/clinical-cancer-research-publishes-results-supporting-divitum-as-a-technology-for-early-evaluation-of-metastatic-breast-cancer-treatment/
...
Forum: Articles of Interest 09-15-2020, 12:50 PM
Replies: 4
Views: 121
Posted By Nguyen
Re: Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6

Abemaciclib with continuous dosing v.s 3 weeks on 1 off for the others CDK4/6, abemaciclib does have less severe neutropenia. Unfortunately, we still have to temporary hold treatment due to low...
Forum: Articles of Interest 09-09-2020, 09:44 AM
Replies: 0
Views: 46
Posted By Nguyen
Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856891/

Don’t remember if I posted this before, can’t believe I am hogging this section (articles of interest), please feel free to tell me to stop. ...
Forum: Articles of Interest 09-09-2020, 08:22 AM
Replies: 4
Views: 121
Posted By Nguyen
Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inh

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559961/

Although an extremely small sample size (4), it is scary to read for us at the moment. I haven't been able to find (yet) more study one way...
Forum: Articles of Interest 09-09-2020, 08:13 AM
Replies: 0
Views: 45
Posted By Nguyen
CDK4/6 inhibitors: The mechanism of action may not be as simple as once thought

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039233/

Nguyen
Forum: Articles of Interest 08-09-2020, 09:05 AM
Replies: 0
Views: 256
Posted By Nguyen
Combination Strategies ...Immunotherapy

Combination Immunotherapy Strategies in Breast Cancer

https://link.springer.com/content/pdf/10.1007/s12609-019-00333-3.pdf

Combination Strategies of Checkpoint Immunotherapy in Metastatic...
Forum: Articles of Interest 07-19-2020, 03:22 PM
Replies: 0
Views: 347
Posted By Nguyen
Six distinct "types" of COVID-19 identified

A bit "dramatized title" in the simplified version, note information have not been through peer reviewed process.

Nguyen

The simplified version:
...
Forum: Articles of Interest 07-17-2020, 07:01 PM
Replies: 0
Views: 213
Posted By Nguyen
Metastatic HER2+ Breast Cancer Treatment Must Move to Personalized Approach

https://www.onclive.com/view/metastatic-her2-breast-cancer-treatment-must-move-to-personalized-approach
Forum: Articles of Interest 07-17-2020, 06:49 PM
Replies: 0
Views: 199
Posted By Nguyen
Leveraging CDK4/6 Inhibitors in Earlier Settings to Boost Outcomes in HR+ Breast Canc

https://www.onclive.com/view/leveraging-cdk4-6-inhibitors-in-the-earlier-settings-to-boost-outcomes-in-hr-breast-cancer
Forum: Articles of Interest 07-17-2020, 01:02 PM
Replies: 0
Views: 203
Posted By Nguyen
Risk of early progression according to circulating ESR1 mutation...

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01290-x

Abstract
Background

Endocrine therapy is recommended as a first-line treatment for hormone...
Forum: her2group 07-11-2020, 08:52 AM
Replies: 1
Views: 552
Posted By Nguyen
Re: Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus

Thanks Lani, somehow I missed this. This info has immediate use for us in our upcoming treatment decision, assuming we can get it via off-label used for her2 positive.

Nguyen
Forum: Articles of Interest 06-25-2020, 08:28 PM
Replies: 0
Views: 469
Posted By Nguyen
Hopefully this will be another weapon for us in the fight.

https://www.icr.ac.uk/news-archive/new-class-of-precision-medicine-strips-cancer-of-its-dna-defences


https://ascopubs.org/doi/10.1200/JCO.19.02404
Forum: Articles of Interest 06-25-2020, 07:26 AM
Replies: 0
Views: 240
Posted By Nguyen
Cardiac monitoring in HER2-positive patients

Cardiac monitoring in HER2-positive patients on trastuzumab treatment: A review and implications for clinical practice
...
Forum: Articles of Interest 06-11-2020, 09:58 AM
Replies: 0
Views: 338
Posted By Nguyen
6/2020:American Cancer Society Guideline for Diet and Physical Activity for cancer pr

If memory serves, main difference with past recommendations is double the amount of daily exercise and intensity.

Nguyen

https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21591...
Forum: Articles of Interest 06-08-2020, 07:34 AM
Replies: 0
Views: 276
Posted By Nguyen
A couple of articles on current immunotherapy for her2 positive BC

Useful background info, albeit a bit long and moderately technical, note "current" <= 03/2020.

Nguyen

https://www.nature.com/articles/s41523-020-0153-3
...
Forum: Articles of Interest 06-05-2020, 09:28 AM
Replies: 1
Views: 484
Posted By Nguyen
Re: Treatment After Progression on CDK 4/6i in mBC

Therapy After Cyclin-Dependent Kinase Inhibition in Metastatic
Hormone Receptor-Positive Breast Cancer: Resistance
Mechanisms and Novel Treatment Strategies
...
Forum: Articles of Interest 05-29-2020, 03:52 PM
Replies: 0
Views: 532
Posted By Nguyen
Tucatinib aka ONT-380

After more than 20+ years ...

https://www.onclive.com/web-exclusives/tucatinib-lead-researcher-explains-significance-of-fda-approval-in-her2-positive-breast-cancer?p=1
...
Forum: Articles of Interest 05-29-2020, 03:37 PM
Replies: 1
Views: 484
Posted By Nguyen
Treatment After Progression on CDK 4/6i in mBC

Not really appropriate title, but there are useful info in it.

Nguyen
...
Forum: Articles of Interest 05-29-2020, 09:00 AM
Replies: 0
Views: 326
Posted By Nguyen
COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the P

https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01293-8

Abstract
Background

Cancer patients have been reported to be at higher risk of COVID-19 complications and...
Forum: Articles of Interest 05-24-2020, 09:20 PM
Replies: 0
Views: 294
Posted By Nguyen
Trastuzumab Deruxtecan Shows Efficacy in HER2+ Breast Cancer Brain Mets

https://www.onclive.com/conference-coverage/esmo-breast-2020/trastuzumab-deruxtecan-shows-efficacy-in-her2-positive-breast-cancer-brain-mets?eKey=RGFkYUFrYUF1c3RpbkRhZEBnbWFpbC5jb20=
Forum: Articles of Interest 04-29-2020, 10:50 AM
Replies: 0
Views: 555
Posted By Nguyen
Discordance in ER/PR/Her2 ; Imaging to detect Hormone Receptor

In the “old” way of doing thing, when primary and met sites were treated as only two “clumps”, the discordant rates between the two were about 17% for er/pr and 8% for her2. With newer technology,...
Forum: Articles of Interest 04-21-2020, 07:48 AM
Replies: 3
Views: 892
Posted By Nguyen
Re: Perhaps something we can do in case we can't get treatment for covid-19.

https://www.nytimes.com/2020/04/20/opinion/coronavirus-testing-pneumonia.html

The above article is along what I posted earlier, but more deterministic. I suggest read comments by other Md's...
Forum: Articles of Interest 04-20-2020, 09:04 AM
Replies: 0
Views: 345
Posted By Nguyen
Vision problems due to anastrozole, bisphosphonate, or ???

My wife vision suddenly (in about 2-3 months time frame) got worse by 3+ diopters. In researching causes, I found the below articles, which might be of interest.

Nguyen
...
Showing results 1 to 25 of 257

 
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