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Search: Posts Made By: gdpawel
Forum: Articles of Interest 06-24-2015, 06:24 PM
Replies: 1
Views: 14,683
Posted By gdpawel
The particular sequence of DNA that an organism...

The particular sequence of DNA that an organism possesses (genotype), or mutational assay, does not determine what bodily or behavioral form (phenotype), or cellular assay, the organism will finally...
Forum: Articles of Interest 06-16-2015, 05:22 PM
Replies: 1
Views: 14,683
Posted By gdpawel
Top 10 Reasons Against Routine Genomic Profiling of Tumors in Patient Care

When they did comprehensive screening for gene mutations at MD Anderson, in a huge number of patients, they found an actionable target in 31%, but, of these 31%, only 10% responded to the targeted...
Forum: Breast Cancer Newsfeed 03-09-2015, 05:43 PM
Replies: 1
Views: 631
Posted By gdpawel
Investigators in Boston Re-Invent the Wheel

https://robertanagourney.wordpress.com/2015/03/09/investigators-in-boston-re-invent-the-wheel/
Forum: Articles of Interest 02-20-2015, 08:49 PM
Replies: 1
Views: 15,219
Posted By gdpawel
Immunotherapy actually works

Larry M. Weisenthal, M.D., PhD., has the patent for a laboratory-testing method that identifies cancer patients who can benefit from new drugs designed to strengthen their immune systems. The testing...
Forum: General Cancer News 09-11-2014, 06:17 PM
Replies: 2
Views: 448
Posted By gdpawel
Genomic analysis has proven to be harder to realize than expected

Therapies targeted at the specific genetics of a patient's lung cancer have proved harder to realize than expected.

Ramaswamy Govindan vividly remembers the first time he treated his patients with...
Forum: Articles of Interest 09-11-2014, 06:16 PM
Replies: 2
Views: 11,800
Posted By gdpawel
Genomic analysis has proven to be harder to realize than expected

Therapies targeted at the specific genetics of a patient's lung cancer have proved harder to realize than expected.

Ramaswamy Govindan vividly remembers the first time he treated his patients with...
Forum: Articles of Interest 09-02-2014, 06:57 PM
Replies: 2
Views: 11,800
Posted By gdpawel
Employing multi-dimensional analyses of both genomic and phenotypic platforms

Robert A. Nagourney, M.D.

Oncologists confront numerous hurdles as they attempt to apply the new cancer prognostic and predictive tests. Among them are the complexities of gene arrays that...
Forum: General Cancer News 09-02-2014, 06:56 PM
Replies: 2
Views: 448
Posted By gdpawel
Employing multi-dimensional analyses of both genomic and phenotypic platforms

Robert A. Nagourney, M.D.

Oncologists confront numerous hurdles as they attempt to apply the new cancer prognostic and predictive tests. Among them are the complexities of gene arrays that...
Forum: General Cancer News 09-02-2014, 05:00 PM
Replies: 2
Views: 448
Posted By gdpawel
Quest for Targeted Therapeutic 'Cocktails' Hits Roadblocks

Mark Pegram, M.D.

The use of cutting-edge technology and bioinformatics to inform clinical decision-making in oncology is still a ways off, according to Mark Pegram, MD, the Susy Yuan-Huey Hung...
Forum: Articles of Interest 09-02-2014, 04:59 PM
Replies: 2
Views: 11,800
Posted By gdpawel
Quest for Targeted Therapeutic 'Cocktails' Hits Roadblocks

Mark Pegram, M.D.

The use of cutting-edge technology and bioinformatics to inform clinical decision-making in oncology is still a ways off, according to Mark Pegram, MD, the Susy Yuan-Huey Hung...
Forum: Articles of Interest 08-17-2014, 07:33 AM
Replies: 9
Views: 11,476
Posted By gdpawel
United States vs Caris Life Sciences, Caris Diagnostics, Miraca Life Sciences

It is familiar and makes me somewhat feel slightly ill, but it was refreshing to see that action is being taken. Just a note, however, that the fraud was not discovered by CMS but instead the case...
Forum: Articles of Interest 08-13-2014, 10:10 PM
Replies: 0
Views: 7,379
Posted By gdpawel
New Discovery Opens the Door to Possible Cure for Heart Disease

Larry Weisenthal, M.D., Ph.D., has announced new findings that unravel mysteries about the root cause of atherosclerosis - the narrowing of blood vessels that leads to heart attack and stroke. It is...
Forum: General Cancer News 07-16-2014, 07:56 PM
Replies: 9
Views: 1,577
Posted By gdpawel
MCED in glioblastoma patients measures favorable responses to Avastin

MCED explains why glioblastoma (the most common primary brain tumor) patients who have favorable responses to bevacizumab (Avastin) develop early calcifications in the tumor bed while glioblastoma...
Forum: General Cancer News 07-16-2014, 07:54 PM
Replies: 9
Views: 1,577
Posted By gdpawel
Predicting tumor response to anti-angiogenic drugs

Advanced imaging techniques may be able to distinguish which patients' tumors will respond to treatment with anti-angiogenic drugs and which will not. In patients newly diagnosed with the dangerous...
Forum: General Cancer News 07-16-2014, 07:53 PM
Replies: 9
Views: 1,577
Posted By gdpawel
Glioblastoma survival improved following FDA approval of Avastin

A new population-based study has found that patients with glioblastoma who died in 2010, after the Food and Drug Administration (FDA) approval of bevacizumab, had lived significantly longer than...
Forum: Articles of Interest 07-09-2014, 11:46 PM
Replies: 16
Views: 6,816
Posted By gdpawel
Personalized Chemotherapy: Understanding Clinical Trials

Personalized Chemotherapy: Understanding Clinical Trials - the Kaplan Meier Graph

In this video of Personalized Cancer Chemotherapy, Dr. Larry M. Weisenthal explains the Kaplan-Meier graph. The...
Forum: Articles of Interest 07-07-2014, 10:30 PM
Replies: 3
Views: 5,206
Posted By gdpawel
An illustrated executive summary to explain what MCED is all about

They made another discovery, a refinement to the elusive mechanism of arterial inflammation, which is in turn the triggering event in atherosclerosis. It's not simply massive calcium accumulation...
Forum: Articles of Interest 07-01-2014, 09:03 PM
Replies: 3
Views: 5,206
Posted By gdpawel
16th International Symposium on Anti-Angiogenic Therapy

The 16th International Symposium on Anti-Angiogenic Therapy: Recent Advances and Future Directions in Basic and Clinical Cancer Research.

Date:February 6-8, 2014

Location:San Diego, California...
Forum: Articles of Interest 07-01-2014, 09:02 PM
Replies: 3
Views: 5,206
Posted By gdpawel
Predictive Biomarker for Anti-Angiogenic Therapy

Endothelial Massive Calcium Accumulation Death (MCAD): Mechanism, Target, and Predictive Biomarker for Anti-Angiogenic Therapy

Presented at the 13th international symposium on anti-angiogenic...
Forum: Articles of Interest 07-01-2014, 09:01 PM
Replies: 3
Views: 5,206
Posted By gdpawel
New Discoveries in Cancer and Heart Disease

MCED: A newly-discovered mechanism of endothelial cell death

Using a patented laboratory test, we have discovered a new cell death pathway in endothelial cells which we refer to as Massively...
Forum: Breast Cancer News 06-12-2014, 09:53 PM
Replies: 9
Views: 5,880
Posted By gdpawel
Cyclin-dependent kinases as therapeutic targets

Cyclin-dependent kinases as therapeutic targets: Examination of palbociclib (PD 0332991) and flavopiridol in human tumor primary culture microspheroids.

Author(s): Robert Alan Nagourney, Eknath A....
Forum: her2group 06-12-2014, 02:02 PM
Replies: 43
Views: 5,486
Posted By gdpawel
Re: Cancer secret to success?! Finding your match!

'lizbeth

For some reason, I didn't get back to you on the Phase II results. It wasn't a "battle of the bands" Physician's Choice vs Molecular Profiling vs Functional Profiling, but it was...
Forum: Breast Cancer News 05-12-2014, 10:16 PM
Replies: 9
Views: 5,880
Posted By gdpawel
Palbociclib Extends PFS in ER-positive/HER2-negative Breast Cancer

Treatment with palbociclib combined with letrozole resulted in significantly improved progression-free survival (PFS) compared with letrozole alone in patients with hormone receptor-positive...
Forum: Articles of Interest 05-07-2014, 03:51 PM
Replies: 16
Views: 6,816
Posted By gdpawel
Many Studies Have 'Elementary Statistical Errors'

You reminded me of a posting I put on cancerfocus. I thought it is apropos.

Prominent Statistician Calls for Greater Collaboration With Clinicians

As a prominent statistician, Andrew J....
Forum: Articles of Interest 05-06-2014, 09:56 PM
Replies: 16
Views: 6,816
Posted By gdpawel
Published Studies Often Conflict With Results Reported to ClinicalTrials.gov

Joseph S. Ross, M.D., MHS.
Yale University School of Medicine

Study results published in major medical journals often conflict with the data its authors have submitted to ClinicalTrials.gov,...
Showing results 1 to 25 of 500

 
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