Forum: Articles of Interest
01-21-2014, 04:00 AM
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Replies: 6
Views: 5,265
Re: Mekinist (Trametinib) a MEK Kinase inhibitor
Elizabeth
That is over my head mostly. I assume you were studying
Porphyria. Heme is the protein in Hemoglobin. I never enjoyed biochemistry but did ok grade wise because it is all memory. Now...
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Forum: Articles of Interest
01-19-2014, 02:43 PM
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Replies: 6
Views: 5,265
Re: Mekinist (Trametinib) a MEK Kinase inhibitor
Elizabeth
I looked at KRAS and got some info. KRAS is a cytoplasmic protein that activates both RAS and P13K. Therefore you get increased cancer cell growth from two signal transdution pathways....
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Forum: Articles of Interest
01-19-2014, 01:57 AM
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Replies: 6
Views: 5,265
Re: Mekinist (Trametinib) a MEK Kinase inhibitor
I dont want to leave things incomplete so I studied BRAF
mutation. Actually it involves that RAF-RAS- MEK-ERK signalling. BRAF is actually B-RAF so it is a RAF protein that has been mutated with a...
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Forum: Articles of Interest
01-19-2014, 01:41 AM
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Replies: 6
Views: 5,265
Mekinist (Trametinib) a MEK Kinase inhibitor
We have had discussions on various inhibitors like C-MET (the inhibiting drug is ARK-195) and P13K inhibitors like
BMK-120 which I believe is caled Buparlisib) I found another signal tranduction...
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