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Forum: her2group 12-15-2006, 02:39 AM
Replies: 5
Views: 1,382
Posted By JohnL
Poor 10 year prognosis for T1N0

Had a quick look at this study. You are right, the data is drawn from individuals diagnosed 1986 - 1992. At this time I think it unlikely that early stage T1N0 patients were offered adjuvant chemo -...
Forum: her2group 05-14-2006, 10:07 AM
Replies: 1
Views: 868
Posted By JohnL
HRT approved for HER2+++ ER/PR-ve

Dear All

Well now, here is an interesting divergence of medical views. So much so I thought I'd post a new thread based upon a letter we've just had. In the previous thread (see somewhere below)...
Forum: her2group 05-14-2006, 03:31 AM
Replies: 13
Views: 1,620
Posted By JohnL
The proportionate benefit for small tumours is...

The proportionate benefit for small tumours is the same as for others. The HERA study included a large sample of small tumour node-negative patients.

Thus even with a post-chemo relapse in the 10%...
Forum: her2group 05-13-2006, 11:12 AM
Replies: 11
Views: 1,759
Posted By JohnL
HRT - The consultant says yes?

Dear All

Well now, here is an interesting divergence of medical views. Let me quote an extract from a letter we have just received from Monica's consultant.

'Monica is T1 G3 N0, ER negative,...
Forum: her2group 05-08-2006, 06:56 AM
Replies: 11
Views: 1,759
Posted By JohnL
HRT and HER2+++

Thanks for the response. That has given us a lot more to think about. I didn't know about the HER2 cells morphing into somthing else, or the estrogen surge theory.

More research required. And a...
Forum: her2group 05-04-2006, 12:40 PM
Replies: 11
Views: 1,759
Posted By JohnL
HRT for HER2+, ER-, PR-

My wife Monica (47) finished her Chemo and 12 months Herceptin about 6 months ago.

We've been talking to her Surgeon and Onc about Hormone Replacement Therapy - which they are quite keen to do to...
Forum: her2group 05-02-2006, 10:43 AM
Replies: 5
Views: 1,229
Posted By JohnL
Underdose

My wife's Onc was the UK head of the HERA trial. Half way through treatment we went on an extended holiday and he seemed quite calm about missing a session or extending the gaps as he explained...
Forum: her2group 03-10-2006, 09:11 AM
Replies: 6
Views: 1,281
Posted By JohnL
FEC used a lot in the UK. Monica did three...

FEC used a lot in the UK. Monica did three courses of FEC 100 before moving on to Taxotere. Not fun, but having an infusion pump for anti nausea drugs and loading up prior to treatment helped. As...
Forum: her2group 03-10-2006, 08:56 AM
Replies: 20
Views: 2,791
Posted By JohnL
Most people here in the UK get it with first AC,...

Most people here in the UK get it with first AC, FEC or Taxotere chemo - if budgets allow. I think it still costs about $3,000 a shot?
Forum: her2group 03-10-2006, 08:47 AM
Replies: 9
Views: 1,535
Posted By JohnL
Our kids were older, but a close friend of ours...

Our kids were older, but a close friend of ours with a brain tumour had two girls under 6 and one 10. She was a very straight, pragmatic type and her decision was whilst being gentle and optimistic,...
Forum: her2group 03-03-2006, 04:18 AM
Replies: 2
Views: 2,379
Posted By JohnL
I found this, which basically says that necrosis...

I found this, which basically says that necrosis - and other treatment related effects - can raise CEA levels.

CEA results should not be interpreted as absolute evidence for the presence or...
Forum: her2group 01-26-2006, 07:39 AM
Replies: 1
Views: 904
Posted By JohnL
Probably refers to the outcome of a specific...

Probably refers to the outcome of a specific study - possibly not a very recent one. Not so many years ago studies on Herceptin recruited patients with late stage disease. Whilst Herceptin often...
Forum: her2group 01-14-2006, 05:58 AM
Replies: 12
Views: 1,747
Posted By JohnL
Toni No problem. It's what the site is about...

Toni

No problem. It's what the site is about and I've had lots of help from others over two years on a steep learning curve.

First the good news. As I sort of hoped, they have indicated a very...
Forum: her2group 01-12-2006, 08:13 AM
Replies: 12
Views: 1,747
Posted By JohnL
Sounds like your friend has been run from pillar...

Sounds like your friend has been run from pillar to post with diagnoses, tests and treatments. However, the good news is that this sounds as though it has been caught very early, which is good.
...
Forum: her2group 01-09-2006, 10:38 AM
Replies: 12
Views: 2,788
Posted By JohnL
Barking mad not to.

Barking mad not to.
Forum: her2group 01-09-2006, 07:23 AM
Replies: 12
Views: 2,788
Posted By JohnL
I saw an extract from a TV programme being made...

I saw an extract from a TV programme being made about this. Quite incredible. More than a few scientists seem to be taking this quite seriously. Dogs' noses are far more sensitive than most chemical...
Forum: her2group 01-03-2006, 07:11 AM
Replies: 21
Views: 3,841
Posted By JohnL
Panic not...! Herceptin if prepared as advised...

Panic not...! Herceptin if prepared as advised can safely be stored for a reasonable period without hurting its efficacy. Even up to 24 hours unrefrigerated.

Stability and Storage Vials of...
Forum: her2group 12-08-2005, 08:03 AM
Replies: 8
Views: 1,548
Posted By JohnL
In the UK they are giving it to node negative...

In the UK they are giving it to node negative patients on the basis that HER2+++ N0 still have a meaningful level of recurrence. Node Negs were part of the HERA adjuvant trial. My wife was N0 and had...
Forum: her2group 12-06-2005, 10:11 AM
Replies: 3
Views: 941
Posted By JohnL
It is a strong antioxidant and protects cells...

It is a strong antioxidant and protects cells from damage. It may not be a good idea to take CoQ10 if you are also having certain types of cytotoxic chemo - as it may actually help protect the cells...
Forum: her2group 12-01-2005, 06:54 AM
Replies: 2
Views: 1,127
Posted By JohnL
Tykerb - new drug? Lapatinib lookalike?

Just spotted this release from GSK yesterday. Never heard of Tykerb and even Google doesn't give any useful links. Is this the new trade name of one of the GS kinase inhibitors undergoing trials?
...
Forum: Articles of Interest 11-11-2005, 06:21 AM
Replies: 5
Views: 2,169
Posted By JohnL
Lancet article

I understand that Roche were so appalled at this article they took an unusual step (drug companies keep their heads down when medicos are arguing as they'll only be accussed of being partisan) of...
Forum: her2group 11-08-2005, 09:51 AM
Replies: 0
Views: 781
Posted By JohnL
HER2/Herceptin 'positive' centres in UK (and elsewhere)

An email from a member of the group has highlighted a particlar (though not uncommon) problem - and perhaps an opportunity for the site.

In the UK, to quote the official figures, 'At present only...
Forum: her2group 10-26-2005, 06:28 AM
Replies: 2
Views: 1,066
Posted By JohnL
Normal HER2 range

The average. number of HER-2/neu gene copies per tumor cell nucleus in samples ranged from 1.28 to 25.50; I think anything over 4.00 is considered an overexpression?

If you want it all in depth,...
Forum: her2group 10-04-2005, 09:19 AM
Replies: 2
Views: 987
Posted By JohnL
Thumbs up Justice done in UK

In the UK the National Health Service has been ducking the herceptin issue for primary and early bc by arguing that 'Roche has not applied for a licence yet, who's to know if it is safe?'
...
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