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Forum: her2group

05-23-2016, 12:56 PM

Replies: 235

Sticky: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

Views: 209,703

Posted By YoungMD

Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

I wanted to add also this. In LM patients, CSF flow abnormalities are common. Circulating cancer cells/emboli obstruct the drainage of the meninges and hydrocephalus can develop, with all of its...

Forum: her2group

05-23-2016, 11:55 AM

Replies: 235

Sticky: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

Views: 209,703

Posted By YoungMD

Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

I apologize, the cytotoxic compliment to IT Herceptin used in Yale is IT thiotepa, 50 mg weekly. It is similar to other combination therapies I've read about in the literature, specifically a...

Forum: her2group

05-21-2016, 10:23 PM

Replies: 235

Sticky: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

Views: 209,703

Posted By YoungMD

Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

In the NYC Metro area, I know for a fact that Dr. Joachim Baehring at the Yale Smilow Cancer Hospital in New Haven, CT treats leptomeningeal disease with an IT Herceptin regimen. 50 mg or 100 mg IT...

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