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Search: Posts Made By: donocco
Forum: her2group 08-30-2019, 09:51 PM
Replies: 6
Views: 287
Posted By donocco
Re: Tamoxifen - 8-10 years?

I looked this p in Pub Med. There was an article in Ther Adv Med Oncology June 18 2018
that addressed this question. The conclusion was that extended Anti-Hormonal therapy with either Tamoxifen or...
Forum: Articles of Interest 08-30-2019, 01:31 PM
Replies: 1
Views: 119
Posted By donocco
Re: Mindfulness‐based cancer recovery and supportive‐expressive therapy maintain telo

Nguyen

Very interesting. One thing confused me so I looked at the reference (#49)

The article stated that the aggressive cancer cells had (ex triple negative) had shorter telomeres than less...
Forum: her2group 08-20-2019, 09:13 AM
Replies: 3
Views: 301
Posted By donocco
Re: 3 questions for alternative/supplement user

When you are dealing with chemo like Adriamycin or Taxol or Cytoxan the use of antioxidant supplements with the chemo is up in the air as far as interference goes. Theoretically yes but in reality ie...
Forum: her2group 08-17-2019, 11:16 AM
Replies: 3
Views: 301
Posted By donocco
Re: 3 questions for alternative/supplement user

Nguyen

The interactions can be a problem. St Johns Wart is a strong enzyme inducer and can lower the serum levels of quite a number of drugs. Best to avoid that one.

The big debate is 'do...
Forum: Breast Cancer Newsfeed 08-15-2019, 10:32 PM
Replies: 2
Views: 74
Posted By donocco
Re: Talzenna (talazoparib)

I made a slight error. I thought I was printing the insert for Talzenna but iit was for Lynparza. I just made a quick glance and Talzenna is only indicated for the BRCA breast cancer. Ill look more...
Forum: Breast Cancer Newsfeed 08-15-2019, 10:23 PM
Replies: 2
Views: 74
Posted By donocco
Re: Talzenna (talazoparib)

After a while you get to understand the what the drug is by the prominant
side effects. If it raises blood pressure it inhibits VEGF in some way. If it causes diarrhea it inhibits EGFR. If it lowers...
Forum: Articles of Interest 08-06-2019, 11:10 AM
Replies: 1
Views: 154
Posted By donocco
Re: Why mouse models fail.

Nguyen

Ill browse trough them later. What you wrote makes sense. Onions
Caffeine and raisins are deadly to a dog. Other mammals no. Im addicted to my coffee

I asked the makers of Tykerb why...
Forum: her2group 07-29-2019, 04:01 PM
Replies: 7
Views: 325
Posted By donocco
Re: Why Capecitabine and Exemestane?

Nguyen

I always tell them Im a pharmacist working with an online group.
You have a lot of knowledge and the pharmacist thing might make them more responsive.
I dont know if they can check the...
Forum: her2group 07-29-2019, 01:58 PM
Replies: 7
Views: 325
Posted By donocco
Re: Why Capecitabine and Exemestane?

Nguyen

I called Novartis the makers of Affinitor. The reason they used Exemestane when the drug was first approved was that the clinical trials with Affinitor was
done on patients who were on...
Forum: her2group 07-29-2019, 01:30 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

The main difference with Tucatinib vs lapatanib is that Tucatinib inhibits Her 2 neu wihout inhibiting EGFR (Her-1). This means less diarrhea. It has good CNS penetration. May be worth trying.
Forum: her2group 07-29-2019, 01:14 PM
Replies: 7
Views: 325
Posted By donocco
Re: Why Capecitabine and Exemestane?

Exemestane (Aromasin) while being an Aromatase inhibitor like Arimidex has a steroid chemical structure like Estrogen. The other 2 dont and this may explain the different mechanism of action that...
Forum: her2group 07-23-2019, 05:17 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

Its Joe Tippens. He has been cancer free for 4 years. He is on Facebook. Appraently other people have used Fenbendazole with some success. Dont forget clinical trials with Phase o ne drugs are about...
Forum: her2group 07-23-2019, 05:01 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

Id also think about that anti-worm drug Fenbendazole. I was impressed reading about the metastatic lung cancer patient Joe (Tibbens ?) Very impressed

Paul
Forum: Articles of Interest 07-09-2019, 02:27 PM
Replies: 1
Views: 276
Posted By donocco
Re: Researchers Turn On PTEN Tumor-Suppressor Protein in Cancer Cells

I did some research on Indole-3 carbinol. The chemical has quite a few anticancer actions, downregulating angiogenesis, downregulating NF-Kappa beta (which contributes to angiogenesis) and...
Forum: her2group 07-04-2019, 01:16 PM
Replies: 2
Views: 261
Posted By donocco
Re: First PI3K Inhibitor for Breast Cancer approved by fda

Piqray (Alpelisib) is approved for Estrogen positive, Her 2 Neu negative postmenopausal
metastatic breast cancer. The dosage is 300mg (two 150mg capsules daily. If side effects become evident (they...
Forum: her2group 07-03-2019, 10:21 PM
Replies: 2
Views: 261
Posted By donocco
Re: First PI3K Inhibitor for Breast Cancer approved by fda

Lani

Thanx for the info. The brand name of Alpelisib is PiqRay. I printed te FDA info and put it on the board tomorrow.
Forum: her2group 06-27-2019, 11:26 AM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

I also was fascinated by the Joe Tippen story. Quackwatch would call it phony but I have long lost any trust in the powers that be as far as cancer is concerned. It has become a very political...
Forum: her2group 06-25-2019, 05:05 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

I read what I printed out about Fenbendazole. It seems to work by blocking microtubules like Taxol but has few side effects unlike Taxol. it also inhibits Glucose uptake in the cancer cells and...
Forum: her2group 06-25-2019, 02:12 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

Felbendazole not Felbamisole. I guess I was confusing Felbendazole with the anti-siezure drug Felbamate. I managed to Xerox some articles about Felbamisole as a treatment for cancer. Sounds very...
Forum: her2group 06-25-2019, 12:41 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

They have been using anti-worm drugs for a long time. The first one used was levamisole.
It seems to stimulate T cell action. It was used for colon cancer after surgery then for some reason it fell...
Forum: her2group 06-24-2019, 01:09 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

Flori

If you don't want anymore traditional treatment you could try one of the Alternative clinics in Southern California that treat cancer with diet and vitamins
that reduce inflammation. I...
Forum: her2group 06-22-2019, 03:16 PM
Replies: 66
Views: 4,452
Posted By donocco
Re: Whack-a-mole next...

SCG

A long shot, but I remember reading about long term control of metastatic pancreatic cancer using Low Dose Naltrexone (4.5mg at bedtime) combined with intravenous Alpha Lipoic Acid 600mg IV...
Forum: Articles of Interest 06-14-2019, 11:15 AM
Replies: 2
Views: 427
Posted By donocco
Re: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

It has been shown that women diagnosed with breast cancer who are in the lowest Vitamin D quartile have worse prognosis and lifespan. As far as prevention goes who knows? It might be good for people...
Forum: her2group 05-30-2019, 12:57 PM
Replies: 9
Views: 593
Posted By donocco
Re: Melanoma Biopsy when almost 5yrs NED BC.

If you get a melanoma removed early it is close to 100% curable. Im not sure this applies to all cancers like they thought in the past. While ultraviolet light exposure is a factor in causing...
Forum: her2group 05-16-2019, 09:30 AM
Replies: 34
Views: 14,289
Posted By donocco
Re: Insurance Frustrations

Becky

It is a very informing article but the problem is the information is on a breast cancer board. Info like this has to be reported by major news networks day after day. Taker CNN for example....
Showing results 1 to 25 of 355

 
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