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Search: Posts Made By: marvass
Forum: her2group 12-13-2017, 01:28 PM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Thanks paul. You and Nina were always a great inspiration for us. I will always remain in this thread to help if i can. And Paul is the best in here on this.

Regards
Mario
Forum: her2group 12-13-2017, 08:14 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Thanks everyone for your very kind posts.
I do not know what advances there was on this kind of cancer except that ONT-380 now called tucatinib is moving quickly in trials, and is very promising. ...
Forum: her2group 02-04-2017, 04:25 PM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Carol passed away yesterday at 2pm gmt+1. Blood pressure fell till spo2 dropped and heart failed. She had an aspiration pneumonia that she could not cope with, mainly because of the taxol, causing...
Forum: her2group 01-23-2017, 08:30 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

MRI of 2 weeks ago show that the three tumors have shrunk to half, showing that taxol and lapatinib is working. However she is having complications with blood parameters and is in hospital to be...
Forum: her2group 12-31-2016, 01:08 PM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

intrathecal herceptin had no side effects even at a dose of 250mg. we did this over 100 times in the past 4.5 years
Forum: her2group 11-17-2016, 01:34 PM
Replies: 235
Views: 209,040
Posted By marvass
Forum: her2group 11-17-2016, 06:28 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Carol is still with mets
7 months ago she was locally irradiated for 3 mets measuring 12,12, and 7 mm. She continued doing IT herceptin at 250mg every 10 or 11 days till today.

In the first 3...
Forum: her2group 03-11-2016, 10:50 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Yesterday we did the first IT herceptin at 200mg. All went well, no side effects.
Forum: her2group 03-10-2016, 05:27 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Does anyone know if more than 150mg of IT herceptin per week was ever used, since my doctor wants to know, since carol's brain mets are not gone with 150mg IT per 10/11 days.
Forum: her2group 09-25-2015, 11:37 AM
Replies: 5
Views: 3,602
Posted By marvass
Forum: her2group 09-25-2015, 11:16 AM
Replies: 8
Views: 2,914
Posted By marvass
Re: Optimum Treatment After Resection of Brain Met

IT herceptinmight be another option
Forum: her2group 09-25-2015, 11:04 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Carol is still doing fine. She now gets the IT and IV treatment of herceptin every 3 weeks, 150mg IT with hydrocortisone, and 6mg per kilo IV. No new mets developed and older ones under control. Hope...
Forum: her2group 06-10-2015, 10:34 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

MRI of yesterday:

All three spots gone and none new seen, thank God.

We have done 10 IT herceptin till now each of 150mg herceptin, and 50mg hydrocortisone, each shot every 10/11 days, i.e. 2...
Forum: her2group 03-09-2015, 01:41 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

First intrathecal herceptin done last friday 6th March after 21 months without any such treatment.

Dose 150mg herceptin and 50mg hydrocortisone.

No pain or funny feelings. All went well, not...
Forum: her2group 02-27-2015, 07:40 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Our oncologist seems to favour for IT herceptin at 150mg again as we did before before trying anything else. Now Carol weighs only 65 kg, so it is a very high dose, 2.3 mg/kilo.
Forum: her2group 02-27-2015, 07:32 AM
Replies: 235
Views: 209,040
Posted By marvass
Forum: her2group 02-26-2015, 10:17 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Thank you Paul, my oncologist in Europe is researching on best way to go, till next week and then we decide from there. Will tell him about the topotecan.
Forum: her2group 02-26-2015, 09:58 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

MRI and CT of today - shock!

3 new lesions can be seen for the first time in over 2 years, 7mm, and 2 others of 4mm.

We have been on IV herceptin 6mg/kg for past 21 months. Now back to...
Forum: her2group 09-08-2014, 03:09 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

If you are her2+ and herceptin is working in all your body except your brain, you may decide to get herceptin to your brain by intrathecal ways. But I am no expert in this. Maybe rolepaul can help...
Forum: her2group 09-05-2014, 01:36 PM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Carol still doing fine. She started to walk again this summer. She has been off IT herceptin for last 16 months now. Last MRI and CT scan done in May showed she is still NED and stroke clearing...
Forum: her2group 01-23-2014, 06:29 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

MRI of this week:
Carol is still NED even now that she is no longer doing IT herceptin for last 8 months.
Seems that damage done with the stroke has opened the BBB for IV herceptin to pass through....
Forum: her2group 11-14-2013, 11:09 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Hi Kaiulani and Paul,

Carol is still doing great, now she can talk very well and she is standing at last, even though she had 3 strokes this summer.
From the experience with the mistakes we did...
Forum: her2group 08-24-2013, 12:55 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Paul, you did local radiation before starting IT herceptin, we did not. On small tumors it worked but not on the 2cm edema. Otherwise IT herceptin cleared over 10 tumors of 7mm or less.
...
Forum: her2group 08-19-2013, 01:13 PM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

My wife had a second stroke 5 weeks ago, but now recovery is going fast. She is close to start standing again. Understanding everything and communicating quite well.

Intrathecal herceptin is...
Forum: her2group 07-12-2013, 01:54 AM
Replies: 235
Views: 209,040
Posted By marvass
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Carol had a WBRT last month due to the edema she had which could not go away with the herceptin. She is now recovering from the stroke she had, rehab exercises everyday. Intrathecal is on hold but...
Showing results 1 to 25 of 105

 
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