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Search: Posts Made By: Rich66
Forum: Articles of Interest 06-09-2012, 02:38 PM
Replies: 3
Views: 2,500
Posted By Rich66
Re: Propranolol (beta blocker)

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Forum: Articles of Interest 06-09-2012, 02:38 PM
Replies: 3
Views: 2,500
Posted By Rich66
Re: Propranolol (beta blocker)

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Forum: Articles of Interest 06-09-2012, 02:34 PM
Replies: 3
Views: 2,500
Posted By Rich66
Propranolol (beta blocker)

Oncotarget. (http://www.ncbi.nlm.nih.gov/pubmed/22006582#) 2011 Oct;2(10):797-809.
Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in...
Forum: her2group 06-08-2012, 09:31 PM
Replies: 28
Views: 2,252
Posted By Rich66
Re: Pertuzumab: Today's The Day

"Who hasnt had herceptin if you are her2 positive? "

Good point. Methinks wires are crossed.
Forum: her2group 06-08-2012, 09:19 PM
Replies: 4
Views: 1,025
Posted By Rich66
Re: Trying to deprive your breast cancer from estrogen may not be so easy after al

Seems like there is a need for personal estrogen detectors..maybe a pill you drop into liquids and see if it changes color. (I have dibs on the patent;)
Forum: her2group 06-08-2012, 09:15 PM
Replies: 28
Views: 2,252
Posted By Rich66
Re: Pertuzumab: Today's The Day

"who have not received prior anti-HER2 therapy or chemotherapy"

Yeah..sure hope this is not enforced.
Forum: General Cancer News 06-08-2012, 09:09 PM
Replies: 9
Views: 1,734
Posted By Rich66
Re: Avastin (bevacizumab)-induced tumor calcifications can be elicited in glioblastom

Potentially HUGE ramifications here. Essentially..the traditional maximum tolerated dose approach of most standard chemos schedules may be undoing Avastin. Roche should be all over this like roaches...
Forum: General Cancer News 06-08-2012, 08:52 PM
Replies: 1
Views: 512
Posted By Rich66
Re: Androgen receptor an additional hormonal target in many breast cancers

Wow. Heard of this but..up to 88% of ER+ BC ise AR+?
So..not to take anything away from Medivation but...other readily available androgen targeted prostate cancer drugs would seem fair game: Lupron...
Forum: Breast Cancer Newsfeed 06-06-2012, 08:59 AM
Replies: 15
Views: 2,319
Posted By Rich66
Re: Genentech's Trastuzumab Emtansine (T-DM1) Reduces The Risk Of Cancer Worsening

Another synergy to be better explored is combining treatment modalities. Much points to the benefits (additive, synergy, or just not conflicting) of combining chemos, bios, hormonals and radiation....
Forum: her2group 05-31-2012, 09:45 PM
Replies: 9
Views: 893
Posted By Rich66
Re: 5 times worse prognosis in those w tumor cells in bone marrow before & 3 weeks af

wow..amazing terrain this is. As long as a patient is informed and willing along the the lines of "Pray", seems worthwhile at this point.
Forum: Breast Cancer Newsfeed 05-27-2012, 09:15 PM
Replies: 15
Views: 1,341
Posted By Rich66
Re: Staggered Cancer Drug Delivery Better Than All In One Go

Same day? What portion of the 24hr schedule?

Sorry..can't promote Devil in the details while remaining vague. I have VERY strong interest in Chronotherapy...
Forum: Breast Cancer Newsfeed 05-27-2012, 09:03 PM
Replies: 15
Views: 1,341
Posted By Rich66
Re: Staggered Cancer Drug Delivery Better Than All In One Go

Cop out response, Greg. ;)

What's the interval in the estimation you promote?
Forum: Breast Cancer Newsfeed 05-27-2012, 08:56 PM
Replies: 15
Views: 1,341
Posted By Rich66
Re: Staggered Cancer Drug Delivery Better Than All In One Go

Only thing that knocks my socks off are strategies prone to working.
Forum: Breast Cancer Newsfeed 05-27-2012, 08:47 PM
Replies: 15
Views: 1,341
Posted By Rich66
Re: Staggered Cancer Drug Delivery Better Than All In One Go

So...translating to real world..morning infusion followed by afteernoon infusion of secondary?
Forum: Breast Cancer Newsfeed 05-27-2012, 07:56 PM
Replies: 15
Views: 1,341
Posted By Rich66
Forum: Breast Cancer Newsfeed 05-27-2012, 07:20 PM
Replies: 15
Views: 1,341
Posted By Rich66
Forum: her2group 05-27-2012, 05:50 PM
Replies: 7
Views: 1,446
Posted By Rich66
Re: another important player in her2 story IDd--role in herceptin resistance

Amanda,
My personal perspective is that Metformin is showing relevance beyond diabetics. It is being investigated in context of overall longevity as well as regarding cancer patients.
...
Forum: her2group 05-25-2012, 09:07 PM
Replies: 7
Views: 1,446
Posted By Rich66
Re: another important player in her2 story IDd--role in herceptin resistance

http://www.ncbi.nlm.nih.gov/pubmed?term=Skp2%20Metformin
Forum: Breast Cancer Newsfeed 05-25-2012, 01:08 PM
Replies: 15
Views: 1,341
Posted By Rich66
Forum: her2group 05-24-2012, 09:52 PM
Replies: 2
Views: 1,173
Posted By Rich66
Re: Noni juice may slow growth of her2+ breast cancer

Interesting. At pretty much the same time, a review (below) had a fairly lukewarm conclusion. Maybe it's especially/uniquely potent against Her2:

Phytother Res....
Forum: Breast Cancer News 05-23-2012, 11:14 AM
Replies: 0
Views: 4,593
Posted By Rich66
Tesetaxel (oral) advances

http://www.marketwatch.com/story/tesetaxel-results-as-initial-chemotherapy-for-women-with-recurrent-breast-cancer-to-be-highlighted-at-asco-2012-05-22
Forum: Articles of Interest 05-23-2012, 10:45 AM
Replies: 2
Views: 2,334
Posted By Rich66
Re: Andrographolide

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Forum: Articles of Interest 05-23-2012, 10:44 AM
Replies: 2
Views: 2,334
Posted By Rich66
Re: Andrographolide

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Forum: Articles of Interest 05-23-2012, 10:43 AM
Replies: 2
Views: 2,334
Posted By Rich66
Andrographolide

Clin Exp Pharmacol Physiol. (http://www.ncbi.nlm.nih.gov/pubmed/22017767#) 2012 Mar;39(3):300-10. doi: 10.1111/j.1440-1681.2011.05633.x.
Andrographolide and its analogues: versatile bioactive...
Forum: her2group 05-21-2012, 10:35 AM
Replies: 4
Views: 695
Posted By Rich66
Re: Her2 extracelluar domain test

Looks like this latest report is supportive. Been bouncing back and forth:
http://her2support.org/vbulletin/showthread.php?p=225648#post2256488
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