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Search: Posts Made By: donocco
Forum: General Cancer News 10-15-2019, 09:58 AM
Replies: 1
Views: 23
Posted By donocco
Re: Risk of genetic seizure disorder: new scoring system

Everything is genetic but genes are relative. A lot of cases of epilepsy are due to head injuries. Still not everyone with the same degree of injury develops epilepsy afterward. If someone has a...
Forum: General Cancer News 10-08-2019, 03:24 PM
Replies: 1
Views: 43
Posted By donocco
Re: New understanding of breast cancer metastasis to bone

Another reason many cancers spread to the bones is that the bones are very rich in cells that produce Interleukin 6 and this is important in many areas of cancer cell proliferation and angiogenesis....
Forum: General Cancer News 10-07-2019, 12:40 PM
Replies: 2
Views: 51
Posted By donocco
Re: Novel drug may be the answer in battling resistance in aggressive breast cancer

Ill see what else I can find about BOS172722. Getting info on the internet is not as quick and easy as in the past. Look up the work of Dr. Linda Vahdat. She treated triple negative breast cancer...
Forum: General Cancer News 10-07-2019, 12:38 PM
Replies: 2
Views: 51
Posted By donocco
Re: Novel drug may be the answer in battling resistance in aggressive breast cancer

I could not find to much info about BOS172722. Apparently the human trials are just starting. They are going to combine it with IV Taxol to see the effect on cancers, particularly triple negative...
Forum: General Cancer News 10-07-2019, 12:15 PM
Replies: 1
Views: 43
Posted By donocco
Re: Understanding treatment and prognosis of male breast cancer

Apparently men can get both inflammatory and Her 2 Neu positive breast cancer. Usually the male breast cancers are both estrogen and progesterone receptor positive. What is rare in men is DCIS, the...
Forum: her2group 10-03-2019, 12:48 PM
Replies: 5
Views: 207
Posted By donocco
Re: Wife's Demise

Ajit

Very sorry to hear of this. The words are lame but it is all I can say

Paul
Forum: General Cancer News 09-18-2019, 10:08 PM
Replies: 2
Views: 98
Posted By donocco
Re: NMDAR receptor is responsible for breast-to-brain metastases, shows study

I think there are already drugs on the market that block glutamate in the brain. Maybe Riluazole, I think Ketamine. Ill have to research gthis. It would be tremendous if we could prevent brain mets
...
Forum: General Cancer News 09-18-2019, 10:06 PM
Replies: 2
Views: 98
Posted By donocco
Re: NMDAR receptor is responsible for breast-to-brain metastases, shows study

Interesting. I think there are medications on the market that block glutamate in the brain. Ill have to research this.
Forum: her2group 08-30-2019, 09:51 PM
Replies: 9
Views: 526
Posted By donocco
Re: Tamoxifen - 8-10 years?

I looked this p in Pub Med. There was an article in Ther Adv Med Oncology June 18 2018
that addressed this question. The conclusion was that extended Anti-Hormonal therapy with either Tamoxifen or...
Forum: Articles of Interest 08-30-2019, 01:31 PM
Replies: 1
Views: 183
Posted By donocco
Re: Mindfulness‐based cancer recovery and supportive‐expressive therapy maintain telo

Nguyen

Very interesting. One thing confused me so I looked at the reference (#49)

The article stated that the aggressive cancer cells had (ex triple negative) had shorter telomeres than less...
Forum: her2group 08-20-2019, 09:13 AM
Replies: 3
Views: 406
Posted By donocco
Re: 3 questions for alternative/supplement user

When you are dealing with chemo like Adriamycin or Taxol or Cytoxan the use of antioxidant supplements with the chemo is up in the air as far as interference goes. Theoretically yes but in reality ie...
Forum: her2group 08-17-2019, 11:16 AM
Replies: 3
Views: 406
Posted By donocco
Re: 3 questions for alternative/supplement user

Nguyen

The interactions can be a problem. St Johns Wart is a strong enzyme inducer and can lower the serum levels of quite a number of drugs. Best to avoid that one.

The big debate is 'do...
Forum: Breast Cancer Newsfeed 08-15-2019, 10:32 PM
Replies: 2
Views: 114
Posted By donocco
Re: Talzenna (talazoparib)

I made a slight error. I thought I was printing the insert for Talzenna but iit was for Lynparza. I just made a quick glance and Talzenna is only indicated for the BRCA breast cancer. Ill look more...
Forum: Breast Cancer Newsfeed 08-15-2019, 10:23 PM
Replies: 2
Views: 114
Posted By donocco
Re: Talzenna (talazoparib)

After a while you get to understand the what the drug is by the prominant
side effects. If it raises blood pressure it inhibits VEGF in some way. If it causes diarrhea it inhibits EGFR. If it lowers...
Forum: Articles of Interest 08-06-2019, 11:10 AM
Replies: 2
Views: 245
Posted By donocco
Re: Why mouse models fail.

Nguyen

Ill browse trough them later. What you wrote makes sense. Onions
Caffeine and raisins are deadly to a dog. Other mammals no. Im addicted to my coffee

I asked the makers of Tykerb why...
Forum: her2group 07-29-2019, 04:01 PM
Replies: 7
Views: 361
Posted By donocco
Re: Why Capecitabine and Exemestane?

Nguyen

I always tell them Im a pharmacist working with an online group.
You have a lot of knowledge and the pharmacist thing might make them more responsive.
I dont know if they can check the...
Forum: her2group 07-29-2019, 01:58 PM
Replies: 7
Views: 361
Posted By donocco
Re: Why Capecitabine and Exemestane?

Nguyen

I called Novartis the makers of Affinitor. The reason they used Exemestane when the drug was first approved was that the clinical trials with Affinitor was
done on patients who were on...
Forum: her2group 07-29-2019, 01:30 PM
Replies: 67
Views: 5,517
Posted By donocco
Re: Whack-a-mole next...

The main difference with Tucatinib vs lapatanib is that Tucatinib inhibits Her 2 neu wihout inhibiting EGFR (Her-1). This means less diarrhea. It has good CNS penetration. May be worth trying.
Forum: her2group 07-29-2019, 01:14 PM
Replies: 7
Views: 361
Posted By donocco
Re: Why Capecitabine and Exemestane?

Exemestane (Aromasin) while being an Aromatase inhibitor like Arimidex has a steroid chemical structure like Estrogen. The other 2 dont and this may explain the different mechanism of action that...
Forum: her2group 07-23-2019, 05:17 PM
Replies: 67
Views: 5,517
Posted By donocco
Re: Whack-a-mole next...

Its Joe Tippens. He has been cancer free for 4 years. He is on Facebook. Appraently other people have used Fenbendazole with some success. Dont forget clinical trials with Phase o ne drugs are about...
Forum: her2group 07-23-2019, 05:01 PM
Replies: 67
Views: 5,517
Posted By donocco
Re: Whack-a-mole next...

Id also think about that anti-worm drug Fenbendazole. I was impressed reading about the metastatic lung cancer patient Joe (Tibbens ?) Very impressed

Paul
Forum: Articles of Interest 07-09-2019, 02:27 PM
Replies: 1
Views: 335
Posted By donocco
Re: Researchers Turn On PTEN Tumor-Suppressor Protein in Cancer Cells

I did some research on Indole-3 carbinol. The chemical has quite a few anticancer actions, downregulating angiogenesis, downregulating NF-Kappa beta (which contributes to angiogenesis) and...
Forum: her2group 07-04-2019, 01:16 PM
Replies: 2
Views: 309
Posted By donocco
Re: First PI3K Inhibitor for Breast Cancer approved by fda

Piqray (Alpelisib) is approved for Estrogen positive, Her 2 Neu negative postmenopausal
metastatic breast cancer. The dosage is 300mg (two 150mg capsules daily. If side effects become evident (they...
Forum: her2group 07-03-2019, 10:21 PM
Replies: 2
Views: 309
Posted By donocco
Re: First PI3K Inhibitor for Breast Cancer approved by fda

Lani

Thanx for the info. The brand name of Alpelisib is PiqRay. I printed te FDA info and put it on the board tomorrow.
Forum: her2group 06-27-2019, 11:26 AM
Replies: 67
Views: 5,517
Posted By donocco
Re: Whack-a-mole next...

I also was fascinated by the Joe Tippen story. Quackwatch would call it phony but I have long lost any trust in the powers that be as far as cancer is concerned. It has become a very political...
Showing results 1 to 25 of 363

 
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