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Search took 0.01 seconds. Search: Posts Made By: agness
Forum: her2group 03-31-2016, 01:19 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"Molecular factors implicated in CNS metastases and LM include E-cadherin–catenin complexes, plasmin, urokinase-type plasminogen activator, metalloproteinases, tissue inhibitors of metalloproteinases...
Forum: her2group 03-28-2016, 09:22 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

I've read about gliadel wafers being used for breast cancer brain mets successfully before. Given that adjuvant chemo is not standard of care for the brain as the first site of metastases and due to...
Forum: her2group 03-22-2016, 01:11 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

A compilation of brain radiation treatment options and review of side effects.

This is something I am experiencing, starting about 5-6 weeks out from partial brain rads. I've not seen it discussed...
Forum: her2group 03-01-2016, 11:39 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"Cramps, or rather complaints of cramps, were the presenting symptom of recognizable and previously unsuspected neurologic dysfunction in 64% (27 of 42) of the identified causes. Therefore, we...
Forum: her2group 01-27-2016, 07:43 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Long-term Survival after Cerebellar Metastasis Resection from Her2 3+ Locally Advanced Breast Cancer (2015)...
Forum: her2group 01-18-2016, 03:23 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"It is estimated that 10-35% of patients diagnosed with breast cancer will develop metastasis to the brain. Although patients with localized disease have a low probability of initial brain metastasis...
Forum: her2group 01-08-2016, 08:46 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Another phase III study tested RSR13 (efaproxiral) in combination with WBRT. RSR13 binds to hemoglobin and reduces its affinity for oxygen thus increasing tissue pO2. In this study of WBRT plus...
Forum: her2group 01-04-2016, 06:56 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Understanding the brain a bit, with an emphasis on the cerebellum. Please add if you can.

The brain is divided up by the dura mater into three regions: the left and right hemispheres...
Forum: her2group 01-04-2016, 06:41 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

The risk of developing LM in breast cancer is actually quite high comparatively and yet the authors claim no increased risk across the patient population of cancer patients with brain mets. Compare...
Forum: her2group 01-04-2016, 06:33 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"Majority (11/18; 61%), developed cerebellar metastases as a resectable, first metastatic site, and 73% (8/11) of these patients had Her2 3+ BC, treated with trastuzumab. Our results suggest that...
Forum: her2group 12-10-2015, 03:31 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases
...
Forum: her2group 12-04-2015, 06:06 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"Patients with BM may be at increased risk of developing LM, especially if the BM are located in the posterior fossa (BMPF). Among patients undergoing craniotomy for BMPF, estimates of the risk of...
Forum: her2group 12-04-2015, 06:03 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Before doing surgery patients should demand SRS to the tumor to reduce the risk of spread during surgery. Even with my large tumor, as I had a good response to dexamethasone to reduce swelling, SRS...
Forum: her2group 12-04-2015, 05:56 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"Taking samples from brain tumors resulting from breast cancer, Jandial and his team found that the breast cancer cells were exploiting the brain's most abundant chemical as a fuel source. This...
Forum: her2group 12-02-2015, 02:07 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Here are some studies out of MD Anderson some of which target HER2 and all brain mets

Clinical Trials Explore Systemic Treatments for Brain Metastases from Breast Cancer (may 2015)...
Forum: her2group 11-30-2015, 12:31 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

I noticed that as well. It seemed to state both though we know they didn't study below stage 4 before introducing it for locally advance disease and now for earlier stage disease as well. The...
Forum: her2group 11-30-2015, 11:50 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

This article is very much about the central nervous system as the first site of mets for HER2.


Incidence of central nervous system metastases in patients with HER2-positive metastatic breast...
Forum: her2group 11-29-2015, 09:58 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

"treatment of subsequent progression is based mainly on expert opinion rather than the results of well controlled trials.3 Although median survival after a diagnosis of brain metastasis now exceeds 2...
Forum: her2group 11-19-2015, 03:46 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Breast cancer brain metastases responding to lapatinib plus capecitabine as second-line primary systemic therapy. (2015)

http://www.ncbi.nlm.nih.gov/m/pubmed/25714248/

About durable responses...
Forum: her2group 11-19-2015, 03:39 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Updates on the Management of Breast Cancer Brain Metastases (2014)

http://www.cancernetwork.com/oncology-journal/updates-management-breast-cancer-brain-metastases

Some good stuff about the risk...
Forum: her2group 11-11-2015, 02:01 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Thanks Paul.

I heard yesterday that Seattle Cancer Care Alliance should be starting an intrathecal anti-HER2 (pertuzumab maybe) in 2016. It will be with Dr Mrugula...
Forum: her2group 11-09-2015, 06:25 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

Canadian Doctors Perform Breakthrough Blood-Brain Barrier Surgery Using Focused Ultrasound (11/9/2015)...
Forum: her2group 11-04-2015, 06:16 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

This is not about brain mets but about radiation-induced changes in primary brain cancer and notes that arteriol venous malformations (slightly different blood vessels than normal) seems to increase...
Forum: her2group 11-03-2015, 05:55 AM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

I had a PCR to neoadjuvant TCHP and no regrowth post surgical resection and LINAC SRS but they are struggling to diagnose me with leptomeningeal disease since my presentation and pattern of...
Forum: her2group 11-02-2015, 09:06 PM
Replies: 58
Views: 34,899
Posted By agness
Re: Compiling Data on HER2 Brain Mets

I'm linking to the section about leptomeningeal disease as that is what I am most interested in right now. The whole article is pretty interesting about understanding symptoms, types of disruptions...
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