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Showing results 1 to 25 of 175
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Posts Made By:
schoonder
Forum:
General Cancer News
06-02-2018, 09:24 AM
Replies:
1
Phase I trial shows safety of investigational drug in treating chronic lymphocytic le
Views:
1,310
Posted By
schoonder
Re: Phase I trial shows safety of investigational drug in treating chronic lymphocyti
at asco:
https://meetinglibrary.asco.org/record/161802/abstract
Authors:
Tejal Amar Patel, Joe Ensor, Angel Augusto Rodriguez, Anna Belcheva, Jorge German Darcourt, Polly Ann Niravath, John G....
Forum:
her2group
11-01-2016, 07:39 AM
Replies:
13
important new report: benefit of TDM1 after herceptin + perjeta raises?
Views:
9,235
Posted By
schoonder
Re: important new report: benefit of TDM1 after herceptin + perjeta raises?
More work is ongoing to improve on t-dm1 based therapy. Following is an excerpt from a recently published world patent application:
"[159] As can be seen with reference to Figure 7, percent...
Forum:
her2group
05-24-2016, 07:01 AM
Replies:
10
News. Back on Kadcyla
Views:
6,707
Posted By
schoonder
Re: News. Back on Kadcyla
18-05-2016 Back
Synthon advances clinical evaluation of anti-HER2 ADC SYD985 in an expanded cohort of HER2-positive metastatic breast cancer patients
Synthon Biopharmaceuticals (‘Synthon’)...
Forum:
her2group
04-18-2016, 10:50 AM
Replies:
4
Anyone on I SPY-2 Trial?
Views:
4,986
Posted By
schoonder
Re: Anyone on I SPY-2 Trial?
Just reported at AACR
...
Forum:
her2group
02-08-2016, 06:23 PM
Replies:
2
BioTe pellets
Views:
3,605
Posted By
schoonder
Re: BioTe pellets
Hi Donna,
Googled subject matter with "biote pellets fda approved" as key and from a variety of returns, selected the two following links.
...
Forum:
Articles of Interest
12-08-2015, 07:35 PM
Replies:
0
Oncothyreon Announces Data for ONT-380 in HER2-Positive Breast Cancer Patients
Views:
23,022
Posted By
schoonder
Oncothyreon Announces Data for ONT-380 in HER2-Positive Breast Cancer Patients
http://ir.oncothyreon.com/releasedetail.cfm?ReleaseID=946155
Forum:
her2group
08-11-2015, 06:26 PM
Replies:
4
PERJETA + Herceptin + docetaxel nearly doubled pCR rates vs Herceptin-- NeoSphere
Views:
2,959
Posted By
schoonder
Re: PERJETA + Herceptin + docetaxel nearly doubled pCR rates vs Herceptin-- NeoSphere
Yes, unlike the docetaxel component in the NeoSphere trial, the very potent maytansine toxin conjugated to the herceptin, boosted the pCR percentile in the ADAPT trial from 6.7 to 40+
Forum:
her2group
08-11-2015, 05:41 PM
Replies:
4
PERJETA + Herceptin + docetaxel nearly doubled pCR rates vs Herceptin-- NeoSphere
Views:
2,959
Posted By
schoonder
Re: PERJETA + Herceptin + docetaxel nearly doubled pCR rates vs Herceptin-- NeoSphere
On a similar note:
Neoadjuvant T-DM1 Shows Promising pCR Rates in HER2+/HR+ Early Breast Cancer | Page 1 Silas Inman @silasinman Published Online: Tuesday, June 23, 2015 - See more at:
...
Forum:
her2group
07-31-2015, 09:58 AM
Replies:
26
Don't want to give up TDM-1
Views:
19,683
Posted By
schoonder
Re: Don't want to give up TDM-1
Since you had to stop an effective treatment with t-dm1 because of a well-known, but manageable side effect, low platelet count, which now has been corrected, I would contact Genentech, producer of...
Forum:
her2group
06-15-2015, 12:12 PM
Replies:
3
Phase II MARIANNE trial results--T-DM1 treatment not superior to herceptin+taxane in
Views:
2,723
Posted By
schoonder
Re: Phase II MARIANNE trial results--T-DM1 treatment not superior to herceptin+taxane
Yes, I was disappointed by the results of the Marianne trial between the T-DM1 arm and T-DM1+Perjeta arm, which came in with a median PFS of 14.1 vs 15.2, and a median DOR of 20.7 vs 21.2 months. The...
Forum:
her2group
11-09-2014, 07:26 AM
Replies:
7
Arizona Voters " Overwhelmingly " pass Right To Try
Views:
2,312
Posted By
schoonder
Re: Arizona Voters " Overwhelmingly " pass Right To Try
Phil, Arizona voters considered this issue a "no brainer". Now it would be nice if this logic could "immediately" be implemented in the policies and directions coming from the FDA.
Forum:
her2group
10-23-2014, 06:20 AM
Replies:
235
Sticky:
Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)
Views:
230,972
Posted By
schoonder
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
To you, your wife, and the medical team THANK YOU for how well you've handled this crisis and the progress thus realized. What an inspiration!
Forum:
Herceptin / Tykerb
10-03-2014, 06:29 AM
Replies:
2
Does TDM1 cross blood brain barrier
Views:
10,080
Posted By
schoonder
Re: Does TDM1 cross blood brain barrier
Recently reported abstract at ESMO re: possible t-dm1 activity in her2+ brain metastases.
https://www.webges.com/cslide/library/esmo/browse/search/6Yy#9faC03oC
Forum:
her2group
09-20-2014, 05:46 PM
Replies:
20
Kadcydla versus neurosurgery and paralysis
Views:
5,250
Posted By
schoonder
Re: Kadcydla versus neurosurgery and paralysis
I don't know if Kadcyla crosses the blood-brain barrier, but at ESMO Conference, later this month the following abstract will be discussed.
"Abstract...
Forum:
her2group
05-15-2014, 01:18 PM
Replies:
235
Sticky:
Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)
Views:
230,972
Posted By
schoonder
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase
ASCO abstract re: T-DM1
"Author(s): Rupert Bartsch, Anna Sophie Berghoff, Margareta Rudas, Elisabeth Bergen, Michael Gnant, Karin Dieckmann, Katja Pinker, Christoph Zielinski, Guenther G. Steger,...
Forum:
General Cancer News
10-24-2013, 11:51 AM
Replies:
1
Patient assistance programs help breast cancer patients to learn more about adjuvant
Views:
1,050
Posted By
schoonder
Re: Patient assistance programs help breast cancer patients to learn more about adjuv
New trial soon to start with T-DM1 in adjuvant setting
http://clinicaltrials.gov/ct2/show/NCT01966471?term=t-dm1&rank=27
Forum:
Clinical Trials
10-14-2013, 11:53 AM
Replies:
6
A Study of PI3-Kinase Inhibitor GDC-0941
Views:
20,069
Posted By
schoonder
Re: A Study of PI3-Kinase Inhibitor GDC-0941
Report from SABCS 2010
[P6-15-02] A Phase Ib Study Evaluating Safety, Tolerability, Pharmacokinetics (PK), and Activity of the Phosphoinositide-3 Kinase (PI3K) Inhibitor GDC-0941 in Combination with...
Forum:
Clinical Trials
10-14-2013, 06:20 AM
Replies:
6
A Study of PI3-Kinase Inhibitor GDC-0941
Views:
20,069
Posted By
schoonder
Re: A Study of PI3-Kinase Inhibitor GDC-0941
GDC-0941 is also being evaluated in a phase I trial with T-DM1. Trial is active, no longer recruiting candidates and approaching anticipated completion date....
Forum:
her2group
09-13-2013, 06:03 AM
Replies:
11
How do you boost your platelets on Kadcyla
Views:
4,024
Posted By
schoonder
Re: How do you boost your platelets on Kadcyla
Since reduction of platelet count is a known side effect of kadcyla and is closely monitored by prescribing oncologists, one would think Roche, as owner of product, would've researched and published...
Forum:
her2group
09-03-2013, 09:39 AM
Replies:
21
Has anyone been on TDM-1 for more than 2 years?
Views:
6,601
Posted By
schoonder
Re: Has anyone been on TDM-1 for more than 2 years?
Phil, since t-dm1 doesn't cross bb barrier and drug's effectiveness prolonging life, and thus increasing possibility of disease metastisizing into brain, I'm somewhat surprised that Genentech which...
Forum:
General Cancer News
08-03-2013, 05:41 AM
Replies:
3
Research aims to provide physicians more targeted approach to treating ER+ breast can
Views:
1,302
Posted By
schoonder
Re: Research aims to provide physicians more targeted approach to treating ER+ breast
Driving force behind I-SPY2 trial is to reduce size of phaseIII trials in order to get new, effective drugs approved for early BC indications in most expedient fashion....
Forum:
her2group
06-13-2013, 05:52 PM
Replies:
16
How long does it take for Kadcyla to work?
Views:
9,323
Posted By
schoonder
Re: How long does it take for Kadcyla to work?
Great news yanyan, very happy your doctor is seeing signs drug is doing the job.
Forum:
her2group
06-13-2013, 10:21 AM
Replies:
16
How long does it take for Kadcyla to work?
Views:
9,323
Posted By
schoonder
Re: How long does it take for Kadcyla to work?
Think Phil got it right, difficult to predict exact moment results of kadcyla, a personalized medicine, can be established. Linked article shows signs of efficacy, improved breathing, to occur after...
Forum:
her2group
06-06-2013, 08:07 AM
Replies:
18
"Help Me"
Views:
2,904
Posted By
schoonder
Re: "Help Me"
Penny, one of the Emilia trial inclusion criteria, a trial which became the basis for T-DM1 approval, required that patients had received:
"Prior treatment for breast cancer in the adjuvant,...
Forum:
her2group
05-09-2013, 05:42 AM
Replies:
27
One year of TDM1. NED!
Views:
5,421
Posted By
schoonder
Re: One year of TDM1. NED!
Great news Michka.
Kadcyla has now also been approved for Swiss use.
http://www.foxbusiness.com/news/2013/05/07/roche-kadcyla-breast-cancer-drug-approved-for-swiss-use/
Showing results 1 to 25 of 175
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