Epigenetic therapy holds promise for cancer management
 

Syndax, a clinical-stage epigenetics oncology company, announced publication of data of entinostat combined with the demethylating agent Vidaza® (azacitidine) showing effect in reducing tumor burden in differentiated tumor cells in animal tumor models of non-small cell lung cancer (NSCLC). The data is being published in the January 15, 2011 issue of Cancer Research.

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Medicinal Food Meets Epigenetics
 

As one of the editors of the Journal of Medicinal Food, Dr. Robert Nagourney, Medical Director at Rational Therapeutics, Inc., in Long Beach, California and an instructor of Pharmacology at the University of California, Irvine School of Medicine, he was asked to review an article on the chemical activities of grape seed extracts. He wrote an editorial describing the interesting findings in this study and their biological relevance.

For many years, naturopaths and health-conscious individuals have recommended the consumption of grape seed extracts. Chemical analyses of grape seeds have provided a treasure trove of active ingredients including resveratrol, anthocyanins, pro-anthocyanins, and numerous terpenes. Many of these substances are potent antioxidants and there is reason to believe that they may have meaningful health benefits.

The most interesting aspect of this well-conducted analysis was the description of a wholly new mechanism of action for the substances found in grape seeds. What the authors found was that the chemical species in grape seed extracts influence gene expression through a process knows as histone acetylation. What makes this so interesting is the fact the histone acetylation is one of the fundamental regulators of genetic expression and a critical part of the new field of science known as epigenetics.

Epigenetics is the field of study that examines heritable attributes that are not incorporated into DNA sequence. These epi-phenomena take existing genes and determine whether or not they will actually be expressed. The reason that this is so important is that it shines a very bright light on the limitations of genomic analyses (studies that examine the DNA sequence in tissues). Clearly, if the consumption of foodstuffs (like grape seed) can alter gene expression then the use of genomic profiles to predict cellular behavior can only be viewed as highly simplistic.

Dr. Nagourney is continually impressed by the complexity of biology and is humbled when we consider the intersecting pathways that take us from gene to function.

http://www.liebertonline.com/doi/abs.../jmf.2010.9401