Herceptin Resistant Protein Discovered
 

<HR style="COLOR: #cc0033" SIZE=1><!-- / icon and title --><!-- message -->Hi .... I Just Heard On Our Local News Channel That 2 Teenage Girls From Southern Calif Discovered The Protein In Her2 Bc Cells That Is Resistant To Herceptin .... The Girls Were Doing A Science Project .... Both Are The Daughters Of Doctors.... THE PROTEIN NAME IS: TDARP ...The Link To The Article Is Below. ... Hoping This Will Get More Attention Very Soon ... I Would Think This Would Be Big News For Us Who Do Not Respond To Hercp Alone ... Has Anyone Else Come Across This News ????

http://www.wcbd.com/midatlantic/cbd/...2-04-0005.html

Regards,

Debbie S.
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dx stage 4 ... 11/04
3.2 cm mass breast & liver mets..
her2 +++ ; er- ; pr -;
11/04 treated with hercp, taxol & carboplatin - every 3 wks
3/05 ned - stopped chemo; hercp only
5/05 reoccurence left breast
6/05 added navelbiene w/ hercp every other week ....
7/05 mascetomy
12/05 ned .... same regiment- changed to every 3 weeks
3/06 & 7/06 ned
9/06 stopped navelbiene.. hercp only.. every 3 weeks...
10/06 pet scan shows positive lymph node in chest area ...
12/06 pet scan had no change from 10/06 scan so I am staying on Hercp only ..... will do a another scan at end of 3/07 .......
4/07 scan showed 4 abnormal nodes in right pec area ... these have increased in activity since last scan... will start back on weekly navelbeine & hercp...
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Debbie,

I did read a bit about it, as they won a prize (not first) in the recent Siemens science fair. The top winners were all girls, and of the 20 finalists, eleven were girls.

I am wondering, though, how they would have gotten access to the tissue of a sufficient number of women who have HER2+ cancer (and have progressed on herceptin) to be sure that the portein they identified actually is the culprit in advancement and not one of many.

It's wonderful that so many girls are interested in science these days. I believe the winners did something similar with resistant TB. In reading the article on the winners I was pleased to see that so many of the girls focussed on projects that deal with issues of health and quality of life. Probably my own prejudice speaking now, but in the past it seemed that the winners were all busy building robots. Not that there's anything wrong with that!