role of HPV(human papilloma virus) in breast carcinogenesis studied
I had seen a paper saying the two were not related, then came across this abstract showing a complicated (indirect) relationship--food for thought?
1123 Human papillomavirus type 16 transform non-invasive breast cancer cells to invasive cells Yasmeen A, Kandouz M, Bismar T, Foulkes W, Mousavi G, Benezra R, Desprez P-Y, Al Moustafa A. McGill University, Montreal, QC, Canada; Memorial Sloan-Kettering Cancer Center, New York, NY; California Pacific Medical Center Research Institute, San Francisco, CA Breast Cancer is characterized by a marked propensity for invasion and spreading through the lymphatic sys- tem, with distant metastases developing in 50–60% of cases. Human papillomaviruses (HPVs) could be important risk factors for breast carcinogenesis and metastasis, as roughly 52% of breast cancers are posi- tive for high-risk HPVs. However, how these viruses enhance susceptibility to breast cancer is not clear. To determine the role of high-risk HPVs in human breast carcinogenesis, we examined the effect of E6/E7 of HPV type 16 in two non-invasive breast cancer cell 123 lines, MCF7 and BT20. We report that E6/E7 induce cell invasion and metastasis abilities of MCF7 and BT20 in vitro and in vivo, respectively, in comparison with the wild type cells. In parallel, we found that HPV type 16 is present in invasive and metastatic breast cancer as opposed to in-situ breast cancer and normal mammary epithelial tissue. We found that E6/E7 up regulate the expression of Id.1, a family member of HLH transcription factors, in MCF7 and BT20 cell lines. To confirm the role of Id-1 in cell invasion and metastasis induced by E6/E7 in mouse normal embry- onic fibroblast (NEF), wild type (wt), and knockout Id- 1 (Id-1[sup–/–) cells. We found that E6/E7 provoke cell invasion and metastasis of NEF-wt but not Id-1[sup–/– cells in vitro and in vivo. Our data suggest that HPV infections play an important role in the development of human breast metastases cancers through ID-1 regulation. |
Thanks Lani. I don't fully understand, but I would not be surprised at all if viruses were involved. BB
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