ER- vs ER+ - kinda old info
 

Hi everyone
Here is the paper whereby I mentioned in a previous thread that ER-negative had a propensity for viscera, and ER-positive for bone. Then someone came along and had mets that contradicted this, so I felt so silly. I searched again for the paper because I knew I had not dreamed this, and here it is - but of course take the information with a grain of salt, as it has already been proven wrong. But just for posterity:

http://cat.inist.fr/?aModele=afficheN&cpsidt=14537617


Kind regards,

I think the point is that her2+status supercedes all the old
 

oversimplifications as to how ER+ or ER- tumors behave. The subtypes described luminal A (ER+her2-), luminal B (ER+her+ among others), her2 group (ER-her2+) and basal (triple negative) are now considered to be the major groups determining how a tumor behaves and how it responds to treatment.

Just as these old oversimplifications (from 2001) have been superceded, it may turn out that these groups contain subtypes within themselves which will change how breast cancer is thought about and treated in the future eg, there may be subtypes such as ER-her2+uPA+ which have different behavior and respond differently to treatment thatn ER-her2+uPA-.

Stay tuned!

Hi Lani
 

What is uPA?

Thanks

Hi Lani
 

What is uPA?

Thanks