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-   -   METADHERIN plays dual role in helping metastasis and maintaining resistance to chemo (https://her2support.org/vbulletin/showthread.php?t=37486)

hutchibk 01-07-2009 10:57 PM

METADHERIN plays dual role in helping metastasis and maintaining resistance to chemo
 
http://www.medicalnewstoday.com/articles/134428.php
"The prognostic significance of MTDH overexpression is independent of other clinicopathological factors, such as ER, PR, HER2, p53 status, and tumor size."

https://cdmrpcures.org/ocs/index.php...8/paper/view/8
"Scientists in the US looking for genomic changes in breast tumor samples found that a gene called metadherin (MTDH) appears to play a dual role in both helping cancer spread (metastasis) and maintain resistance to chemotherapy. They said this research identifies MTDH as an important new target for the treatment of high risk breast cancers."

(PS, the study that discovered this was funded by Komen for the Cure. They provided Kang with a two-year $250,000 grant in 2005.


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