HER2 Support Group Forums - Breaching the Gates of Troy: Drug Delivery Systems for the Central Nervous System

http://www.materialsviews.com/detail...us_System.html

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Choline is a molecule abundant in the CNS environment, the high concentration indicating that it can travel freely across the BBB, and previous studies had demonstrated the use of choline and glucose as transporter paths for a limited range of drugs. The research reported by the Chinese team takes another step along the road, coupling a choline derivative to a nanoparticle-based gene-delivery system in order to cross the barrier and release the drug into the CNS environment. Fluorescent tagging of the compounds for in vitro testing showed that the choline, acting as a Trojan horse, successfully carried its contents into the CNS, concentrating in areas where the choline demand was greatest.