Anybody else ER+/PR+/HER2+++ BRCA 2 +?
 

If you are triple positive and BCRA2 +,
Will you share your treatment protocol?
I had stage 1 IDC 1.3 cm partial mastectomy of the right breast 1/14
Taxol/Herceptin 7/12 rounds

I plan oopherctomy this summer and bilateral mastectomy with reconstruction in the fall. Currently NED!

I want to stop the taxol, but continue Herceptin. I have started experiencing chemo brain this week. That is scary!

Please share your experience and any recommendations.

Thank you!
Loren

Re: Anybody else ER+/PR+/HER2+++ BRCA 2 +?
 

Just saw your query.. No I tested negative for BRCA.
I don't know how/if that might influence your protocol. The FORCE website might be helpful
www.facingourrisk.org

Warmly ,
Marcia

Re: Anybody else ER+/PR+/HER2+++ BRCA 2 +?
 

You can see my signature and what I have done!!

Re: Anybody else ER+/PR+/HER2+++ BRCA 2 +?
 

I am curious - why did you opt out of the Platinum Salt and only chose the Taxane for chemotherapy? I have always heard that Carboplatin or Cisplatin have effectiveness for the BRCA cancers.

I went on the National Cancer Institute's website and found a ton of info on the BRCA mutations.

I have a lot to say about the chemo brain. I was not aggressive enough about managing it with my medical team. I should have dose reduced the taxane sooner and skipped the final 2 treatments. I see that you have done 7/12 treatments? Are these weekly? Every 3 weeks? Most have 4 - 6 treatments total on the 3 week schedule. What's the story with 12 treatments?

I sacrificed significant cognitive function. I feel it reduced my quality of life for a minimum of 5 years, especially my work life.

I am not going to tell you more chemo is better. It doesn't really work like that.

You've already done 7 chemos and have a plan for prevention with the oophrectomy and the double mastectomy. And you will be on Herceptin for the full year. Sounds like a wise plan to me.

Re: Anybody else ER+/PR+/HER2+++ BRCA 2 +?
 

My oncologist said new research indicated 12 weekly treatments of Taxol with Herceptin was just as effective (if not more) as TAXOTERE/Carbo platinum/Herceptin 6 doses every three weeks. She said it was less toxic, too.
I did one more treatment 10 days ago. I opted out of taxol last week because the peripheral neuropathy was awful!
I meet with onco tomorrow. When we started the treatment plan, I did not know that I was BRCA 2+.
I want to discontinue Taxol. My brain is clearing and the neuropathy is lessening. But I have fear it will be permanent if I continue.
Thanks for the info. You're very resourceful.

Re: Anybody else ER+/PR+/HER2+++ BRCA 2 +?
 

Hello again,

I think you are on top of the cancer and your options. Good luck with convincing the oncologist to drop the last 4 taxanes infusions.

You also have quite a bit of anesthesia in your future with the upcoming surgeries. That was tough on my brain function.

I know what you mean about the BRCA testing. It would be better if they tested sooner, but they usually don't.

Exercise helped me quite a bit. You have the challenge of the neuropathy, but brisk walking is so healthy for us cancer survivors.

Keep us posted