endocrine followed by t-dm1 and back to endocrine
Hello,
Anyone here has experience with the treatment pattern of endocrine (tamoxifen OR aromatase inhibitor) followed by T-Dm1 then back to endocrine? Essentially I am looking for any evidence that T-Dm1 might be able to reverse hormonal treatment resistance. Thanks, Nguyen |
Re: endocrine followed by t-dm1 and back to endocrine
Nguyen,
That's an interesting question. I don't recall reading about such an effect, but it would be great if it were true. Amy |
Re: endocrine followed by t-dm1 and back to endocrine
There are data (including our own experience some years back) on Trastuzumab reverses/reduces endocrine resistance. Since Trastuzumab is part of T-Dm1, I hope the effect will be repeated. Also there is this concept and data that if there is a significant time span (years) a drug that stopped working might work again.
Linda's treatment history: 07/2014 - current: T-DM1 (knock on wood a million times) 02/2014 – 06/2014: Everolimus (5mg), Exemestane, herceptin 08/2013 – 01/2014: Femara, herceptin 12/2012 – 07/2013: 4mg estradiol, herceptin 08/2012 - 12/2012: Fulvestran 500mg, exemestane, Herceptin (Stop everolimus due to mouthsores) 05/2012 - 08/2012: Everolimus (10mg), Exemestane, Herceptin, Zometa 08/2011 - 05/2012: Herceptin, Tykerb, Femara, Zometa 08/2010 - 08/2011: Herceptin, Femara, Zometa 09-2009 - 08/2010: Herceptin and estradiol (6mg) 09/2008 - 09/2009: Herceptin, Fulvestrant, Femara 03/2008 - 09/2008: Herceptin, Exemestane, Oophorectomy 01/2005 - 03/2008: Herceptin (readded) and Femara 07/2004: It returned again via several small nodules in the lung 10/2002: NED (via CT and CA27.29)! 10/2001 - 01/2005: Femara, (Fosamax) 12/2000 - 10/2001: Herceptin and Navelbine 12/2000: lung metastatic was diagnosed (a few small nodules) 02/1998 - 12/2000: Daily Tamoxifen 05/1997 - 04/1998: Modified Radical Mastectomy, many many cycles of chemo regiments (CAF,Taxol, Carpoplatin, Thiotepa, Navelbine, Taxotere), including HDC, and radiation 05/1997: First diagnosed with BC stage 3A, ER+, PR+, HER2 +, poorly differentiated, nuclear grade 3. |
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