Could Zometa,Fluvastatin & Herceptin act in synergy?
Two unrelated laboratory experiments indicate that on one hand Zometa enhance Fluvastatin (an approved anticholesterol drug also called Lescol) & on the other hand Fluvastatin enhances the activity of Herceptin.
All three drugs are approved & have relatively moderate side effects. Could they be combined in treating breast cancer patients? Anyone willing to ask her onc? http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ProduktNr=223857& Ausgabe=231811&ArtikelNr=93006 Zoledronic Acid (Zometa®) Enhances the Cytotoxic Effect of Gemcitabine and Fluvastatin: In vitro Isobologram Studies with Conventional and Nonconventional Cytotoxic Agents http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro |
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