Navelbine + Gemcitabine
Onco suggested Navelbine + Gemcitabine . As per onco disease not responding to aggressive treatment being given .What are other options at this stage ? Has anybody got bone metastates cleared in PET scan after chemo ?
_________________________________________________ Age 38 years 17 Feb 2010 – Mammography – Mass in right breast suspicious of malignancy 19 Feb 2010 – FNA from right breast – Duct carcinoma cells seen 04 Mar 2010 – Right radical modified mastectomy – tumor 3X3X2, LN1/19 +ve 15 Mar 2010 – Hormone receptor – ER negative, PR negative, c erb B2 – positive score3 25 Mar 2010 – Detection of HER-2/neu by FISH - positive 1 Apr 2010 – Chemotherapy Started – 3 CEF + 4 Docetaxel + Herceptin (3wkly X 17) 30 May 2011 – Course of Herceptin completed 9 Aug 2011 – CT Scan – focal lesion 3.2X2.9cm in segment IV of liver 10 Aug 2011 – PET-CT Scan – solitary hepatic metastasis, precaval LN suspicious mets 15 Aug 2011 – Oral chemotherapy started – Tykerb 250, Xeloda 500 28 Feb 2012 – PET-CT Scan –hepatic metastasis,lymphatic metastasis,skeletal metastasis 03 Mar 2012 - I.V. 3 weekly chemo started PacliALL (Paclitaxel ) given 05 May 2012 - PET CT Scan " Hypermetabolic hepatic , lymphatic and osseous metastates . Paclitaxel ineffective. |
Re: Navelbine + Gemcitabine
Hi Alex,
Did you have Herceptin with the paclitaxel? This seems like a good time for a second opinion, preferably at an NCI-designated comprehensive cancer center if you're in the US ( http://cancercenters.cancer.gov/canc...ers-list2.html . There is no specific sequence of drugs. Although it seems like each onc has their own favorites, it's essentially a matter of using the tools in the toolbox as slowly as possible, weighing toxicities (side effects) against efficacy. Just because response to a taxane was disappointing doesn't necessarily mean that the cancer won't respond to other chemos and/or anti-HER2 agents. Here (copy/pasted below) is a list of chemos plus Herceptin (or Tykerb) from the NCCN guidelines. I found these at "advancedbc.org" which also has two pages of "treatments in common use", listed with links to more info about each one. Look to the sidebar on the left for those pages at this site: http://www.advancedbc.org/ Preferred Chemotherapy Regimens for Recurrent or Metastatic Breast Cancer (pages BINV-M 1-6)
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Re: Navelbine + Gemcitabine
Stephanie had had 27 rounds of Taxol, Navelbine, and Herceptin before her liver attained the NED status. Below is her treatment history:
Found suspicious lump 9/2000 Lumpectomy, then node dissection and port placement Stage IIB, Grade 3, ER & PR - Adriamycin 12 weekly, taxotere 4 rounds 36 rads 3 mos after rads liver full of tumors, Stage IV Jan 2002 Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED! 2003 & 2004 no active disease - 3 weekly Herceptin + Zometa Jan 2005 two mets to brain - Gamma Knife on Jan 18 All clear until suspicious spot on Jan 2006 brain MRI & PET Brain surgery on Feb 9, 2006 - no cancer, all radiation necrosis Continue as NED while on Herceptin & quarterly Zometa Fall-2006 - off Zometa - watching one small brain spot (scar?) 2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava 2008 - Nov. 2009 Brain and body still NED! Port removed and scans in Dec. Dec 2008 - stop Herceptin - STILL NED in late 2011 - on wing & prayer Vaccine Trial at U of W begun in Oct. of 2011 |
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