Understanding Perjeta & Perjeta with Herceptin
Inhibit Dimerization for More Comprehensive HER2 Blockade
HER2 dimerization inhibition with PERJETA<sup>1</sup>
Proposed mechanism of action of PERJETA with Herceptin video The video below shows the proposed mechanism of action of PERJETA in combination with Herceptin. When used together, the combination provides a more comprehensive blockade of HER2-driven signaling pathways.<sup>1</sup> Note: This video contains sound, so please adjust the volume. http://www.perjeta.com/hcp/images/hc...load-video.pngAs seen in preclinical models: PERJETA targets a different domain on the HER2 receptor than Herceptin (trastuzumab), allowing the combination to provide a more comprehensive blockade of HER2-driven signaling pathways.<sup>1,8,9</sup> Proposed mechanism of action of PERJETA with Herceptin 1. http://www.perjeta.com/hcp/images/hcp/moa/step-1.jpg PERJETA binds to subdomain II and blocks ligand‑dependent HER2 heterodimerization with HER1, HER3, and HER4.<sup>1</sup> 2. http://www.perjeta.com/hcp/images/hcp/moa/step-2.jpg PERJETA inhibits HER2:HER3 dimer formation and downstream signaling, while also mediating antibody‑dependent cell-mediated cytotoxicity (ADCC).<sup>1,4-6</sup> 3. http://www.perjeta.com/hcp/images/hcp/moa/step-3.jpg Herceptin binds to subdomain IV and disrupts ligand‑independent HER2 signaling. Herceptin also mediates ADCC.<sup>8,9</sup> 4. http://www.perjeta.com/hcp/images/hcp/moa/step-4.jpg PERJETA + Herceptin provide a more comprehensive blockade of HER2-driven signaling pathways.<sup>1,8 http://www.perjeta.com/hcp/moa;jsess...677.gxe501b-m1 </sup> |
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