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Merridith 03-20-2005 07:13 PM

This is a 6 page article:


Introduction
Can Schedule/Sequence Alterations Affect Outcomes?
Evaluating New Therapeutic Regimens in the Metastatic Setting
Future Directions in Chemotherapeutic Management
Conclusions
References

http://www.medscape.com/viewarticle/491728

al from canada 03-20-2005 08:34 PM

Great article Merridith.
One thing all of these articles refers to is Response Rate, Time to Disease Progression (TTP), and Overall Survival (OS). My question is: many of these novel therapies or novel combinations have a significantly different TTP but have a non-significant OS. In otherwords, why is it if we can stall the TTP you still died just as early as the lower TTP study arm? Is this a statistical anomoly or a medical fact?
Al


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