Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

Saw this news this morning and was overjoyed. Great
minds THINK, and I admire them.

https://www.cnbc.com/2020/09/26/how-...eficiency.html

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

My latest rapid response to a BMJ editorial letter listing 40+ papers (so completed studies) (some published some pre-print) looking at the impact of vitamin D levels on COVID + patients

They all point to vitamin D deficiency being a COVID-19 risk factor.

There is a vast amount of papers on the underlying biology of vitamin D and immune function.

Depressing there is so much information but so little being done.

As noted in the response the Gates Foundation have excluded vitamin D from funding - why is mystery and utterly perplexing - if there are very likely cheap effective mitigation strategies why not do the necessary research so they can be put into clinical practice ???????

IF anybody knows Gates, Bezos or other persons of influence please show them the letter - the refs are all there to check etc etc. - getting D levels up in the at risk groups may not help pharma or medical system profits but could help save lives, economies, and change the face of this pandemic

https://www.bmj.com/content/371/bmj.m3872/rr-5


Useful video https://youtu.be/cSh4HFNaCkA

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

https://www.bmj.com/content/371/bmj.m4912

Nguyen

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

https://www.nutraingredients.com/Art...-s-governments

People are listening to you RB. Stay safe

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

Glad to read this counter point.

Nguyen

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

For your monthly monitor (or when any opp arrives), you can ask for vitamin D level check as part of the blood drawn. You can also ask your regular PCP for this and not wait for an oncologist order.

Nguyen

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

Sorting Out Whether Vitamin D Deficiency Raises COVID-19 Risk

https://jamanetwork.com/journals/jam...m_medium=email

Op-Ed: Don't Let COVID-19 Patients Die With Vitamin D Deficiency

https://www.medpagetoday.com/infecti.../covid19/90530

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

It needs to be said as a PSA, vitamin D deficiency is linked to a ton of health problems and increased mortality. Not just covid-19.

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

The benefit of vitamin d supplements for those with deficiencies is huge, but the benefit to those without a deficiency are still quite significant, sitting at around a 20% reduction in respiratory infections. I'd take a 20% less chance of complications with COVID19 for no downside.

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

I've used Vit D3 plus k2 cause I was Vitamin D deficience. However, there are evidence that Vitamin D Supplementation could reduce risk of Influenza and COVID-19 Infections and deaths.

I take 5,000 iu Vitamin D3 from vitaminexpress, one per day. Feel much more balanced. I actually take it before bed and I feel like I wake up more refreshed when I do.

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

https://www.timesofisrael.com/1-in-4...israeli-study/

1 in 4 COVID patients hospitalized while vitamin D deficient die – Israeli study

"Results Of 1176 patients admitted, 253 had VitD levels prior to COVID-19 infection. Compared with mildly or moderately diseased patients, those with severe or critical COVID-19 disease were more likely to have pre-infection vitamin D deficiency of less than 20 ng/mL (OR=14.30, 95%, 4.01-50.9; p < .001); be older (OR=1.039 for each year, 95% CI for OR, 1.017-1.061; p< .01), and have diabetes (OR=2.031, 95% CI for OR, 1.04-3.36; p= 0.038). Vitamin D deficiency was associated with higher rates of mortality (p<0.001) and comorbidities including COPD (p=0.006), diabetes (p=0.026), and hypertension (p=0.016)." https://www.medrxiv.org/content/10.1....04.21258358v1

Anther study to add to a long list.

Please also see

https://academic.oup.com/jcem/advanc...gab405/6294179

Calcifediol treatment and COVID-19-related outcomes


also referred to in the other D thread

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

Another new one of many


Vitamin D deficiency is associated with higher hospitalisation risk from COVID-19: a retrospective case-control study

https://academic.oup.com/jcem/advanc...gab439/6303537

CONCLUSIONS
Vitamin D deficiency is associated with higher risk of COVID-19 hospitalisation. Widespread measurement of serum 25(OH)D and treating any unmasked insufficiency or deficiency through testing may reduce this risk.

Re: Coronavirus - is low vitamin D a factor - vitamin D and respiratory conditions
 

Re this link . . .

https://www.bmj.com/content/371/bmj.m4912




There are 86 studies listed and analyzed here https://vdmeta.com/

How much evidence do you need before funding the necessary double blinded studies to confirm that vitamin D factors in COVID-19 risk and that the hydroxylated products used in a hospital setting likely substantial reduce ICU and mortality risk . . .

Smoking was accepted to be detrimental to health using Bradford Hill criteria - viz taking a broader view of evidence . . . surely enough vitamin D evidence has accumulated to justify funding. . .

It is hard to follow all of this and not be a mix of: depressed, resigned. infuriated, at the 'stupidity' of it all.


It would be so easy to be objective, and curious, and fund the necessary research to try and bolt this down - and ideal study for Oxford UK RECOVERY - no response - or for big funders - no enthusiasm so far . . . I have tried . . . and without funding hospital groups will not undertake the research - that is the nature of the system we have created - research is another revenue stream and ultimately controlled by finance considerations . . .

The Semmelweis effect (The Doctor Who Championed Hand-Washing And Briefly Saved Lives) https://www.npr.org/sections/health-...-women-s-lives is indeed live and well - same old 'humanity' - same old behavioral traits and drivers - pride, money, and following the herd / peer pressure . . . same result . . . and that in the case of Semmelweis meant 30 years more deaths of mothers from puerperal fever after delivery of babies by surgeons who had performed autopsies without disinfecting their hand first - particularly ironic in the circumstances

Who will be the one to give this the impetus it needs to happen - I have neither the profile nor contacts to do so - and am one of many of a large group who have been trying for over a year . . .




SUMMARY from https://vdmeta.com/

"•96% of 27 vitamin D treatment studies report positive effects (15 statistically significant in isolation).
•Random effects meta-analysis with pooled effects using the most serious outcome reported shows 78% and 56% improvement for early treatment and for all studies (RR 0.22 [0.12-0.39] and 0.44 [0.34-0.57]). Results are similar after restriction to 24 peer-reviewed studies: 83% and 57% (RR 0.17 [0.07-0.42] and 0.43 [0.33-0.56]), and for the 15 mortality results: 78% and 67% (RR 0.22 [0.12-0.43] and 0.33 [0.22-0.50]).
•Late stage treatment with calcifediol/calcitriol shows greater improvement compared to cholecalciferol: 80% versus 48% (RR 0.20 [0.13-0.31] and 0.52 [0.33-0.82]). The only treatment study reporting a negative effect is a very late stage cholecalciferol study.
•Heterogeneity arises from many factors including treatment delay, patient population, the effect measured, variants, the form of vitamin D used, and treatment regimens. The consistency of positive results across a wide variety of cases is remarkable.
•Sufficiency studies show a strong association between vitamin D sufficiency and outcomes. Meta analysis of the 59 studies with pooled effects using the most serious outcome reported shows 56% improvement (RR 0.44 [0.36-0.53]).
•While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 7% of vitamin D treatment studies show zero events in the treatment arm.
•Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. All practical, effective, and safe means should be used. Not doing so increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage.
•All data to reproduce this paper and the sources are in the appendix.