Kadcyla and Keytruda Information and side effects
 

One of the reasons I love our Her2 support group, is that I learn so much from others past experience, and even going back and reading my own postings on treatment side effects, that I am doing again. I want to share my new adventure with you all, in hopes that it may help someone else looking at this treatment option. I can't seem to find anyone else doing this at the moment.

I will be adding Keytruda (Pembrolizumab) to my treatment schedule, starting this Thursday. I am really excited and nervous at the same time. When you read the list of possible side effects of pembrolizumab, it is a decision not to be taken lightly.
This is a clinical trial being done in Arizona using this combo. https://clinicaltrials.gov/ct2/show/...eytruda&rank=1

I will update on my progress and side effects as I go along.

Here are some interesting articles, relating to why this combo may be so effective.
http://www.humanpathol.com/article/S...%2900327-5/pdf

Also for anyone considering a PD-1 blocker, taking bifidus bacteria is a must. Here is a study which explains the finding on this.

http://www.ncbi.nlm.nih.gov/pmc/arti...rticle_256.pdf

If you have access to Science, this is the study mentioned http://www.ncbi.nlm.nih.gov/pmc/arti...rticle_256.pdf

I will update on my experience, side effects and results as I go along.

Healing wishes
Fern

Re: Kadcyla and Keytruda Information and side effects
 

Fern,
looking forward to your updates. I really hope this treatment is the one that does magic for you.

Re: Kadcyla and Keytruda Information and side effects
 

Fern, I'm a newbie in this group, but looking forward to your updates. And wishing you a smooth treatment and little if non side effects.

Re: Kadcyla and Keytruda Information and side effects
 

Hi Fern! Thanks so much for taking the time to post about this. Here's hoping it knocks your mets out of the park and you back to NED.

Carol Ann

Re: Kadcyla and Keytruda Information and side effects
 

Fern,
Hope this treatment works for you and that your side effects are minimal! Looking forward to your updates.

Take Care,
Brenda

Re: Kadcyla and Keytruda Information and side effects
 

Here is my update on Kadcyla and Keytruda combined. After 4 cycles, there is progression in my lungs, as well as numerous brain mets, not visualized 3 months prior. So it seems this combo was not a good one for me. Most of the mets are in the cerebellum and the brain stem. So back to the drawing board. I have never had brain mets develop so quickly. The Keytruda also really increased my AST, Alkaline Phosphatase, lowered my albumin levels and reduced my lymphocyte count.

I was hoping this would be a winner, but it wasn't :(

Re: Kadcyla and Keytruda Information and side effects
 

Hi Fern,

Well this SUCKS. I am so sorry. Words aren't enough.

Hoping Kadcyla alone will stop things in their tracks for you.

Carol Ann

Re: Kadcyla and Keytruda Information and side effects
 

Hi Fern
I am so sorry this is happening. I was hoping with you that it would be a good combo. Now you have to figure out a new plan with your oncs so I am sending hugs and strength across the ocean.

Re: Kadcyla and Keytruda Information and side effects
 

Oh Fern, I am so sorry to read your update. You are such a remarkable woman and I know this has to be so upsetting for you. Praying for another combo that will be the winner for you! Stay strong!