focused ultrasound delivers antibody therapy vs bc brain mets
ADVANCED SEARCH
EurekAlert! Science News A service of the American Association for the Advancement of Science NEWS RELEASE 13-OCT-2021 World-first clinical trial demonstrates focused ultrasound can deliver antibody therapy to breast cancer metastases in the brain Researchers at Sunnybrook Health Sciences Centre published results Oct. 13 in Science Translational Medicine Peer-Reviewed Publication FOCUSED ULTRASOUND FOUNDATION PrintEmail App MR Images of Metastatic Tumor Reduction IMAGE: MR IMAGES SHOWING REDUCTION IN SIZE OF METASTATIC TUMORS AFTER FOCUSED-ULTRASOUND DELIVERY OF ANTIBODY THERAPY THROUGH BLOOD-BRAIN BARRIER. view more CREDIT: SUNNYBROOK HEALTH SCIENCES CENTRE In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, have demonstrated that magnetic resonance (MR)-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain. In this Phase I clinical trial for Her2-positive breast cancer patients, the Sunnybrook team captured images of the antibody therapy, trastuzumab (or Herceptin), precisely targeting tumors in the brain after using Insightec’s Exablate Neuro focused ultrasound device to temporarily and noninvasively open the blood-brain barrier (BBB) and enable intravenous trastuzumab to more effectively access tumor sites. Antibody therapies can help the immune system fight cancer cells, and they are often used in combination with radiation and chemotherapy. However, the BBB presents a challenge when attempting to target sites in the brain. The BBB is a layer of cells lining blood vessels that protects the brain from viruses, bacteria, and other toxins – but it can also prevent therapeutics, such as trastuzumab, from reaching the brain in high enough concentrations to be effective. “This is the first visual confirmation that focused ultrasound can improve the delivery of targeted antibody therapy across the BBB,” says Dr. Nir Lipsman, the study’s principal investigator and director of the Harquail Centre for Neuromodulation at Sunnybrook. “These are preliminary, but very promising, results that with continued research have implications well beyond brain cancer for other neurological conditions, including Parkinson’s disease and Alzheimer’s, where the blood-brain barrier poses a challenge to drug delivery.” The results from the first four patients in this 10-patient trial were published today in Science Translational Medicine in an article entitled “MR-guided focused ultrasound enhances delivery of Trastuzumab to Her2-positive brain metastases.” Metastatic breast cancer, also known as Stage IV breast cancer, starts in the breast and can spread to the brain, bones, liver, or other organs. Current treatments for breast cancer brain metastases include open neurosurgery, radiation, and chemotherapy. However, depending on the location and number of brain metastases, options for surgery and radiation may be limited, and it can be difficult for therapies to effectively reach tumors in the brain. “The early data in this study suggests delivery of antibody therapy directly to tumors using focused ultrasound may impact treatment efficacy, with tumors slightly decreasing in size, with varying results for patients between 7 and 31 percent during the study – on average to 21 percent,” says Dr. Rossanna Pezo, medical oncologist in the Odette Cancer Centre at Sunnybrook. “The reduction in tumor size is promising but should be interpreted with caution as further research on a larger scale is needed.” These results set the stage for the possibility of delivering a host of both established and novel therapies for numerous brain conditions that otherwise cannot gain access to the brain. Sunnybrook is a Focused Ultrasound Center of Excellence – the only Canadian site to be recognized as such by the Focused Ultrasound Foundation, which was one of the funders of this clinical trial. “The multidisciplinary team at Sunnybrook are pioneers in the use of focused ultrasound to treat a variety of brain disorders,” says Neal F. Kassell, MD, chairman of the Foundation. “This world-first study demonstrating the effectiveness of focused ultrasound to open the BBB for facilitating delivery of antibodies to the brain is an important milestone in the development of new approaches for treating brain tumors and other neurological disorders. We are pleased to be partnering with this esteemed group.” JOURNAL Science Translational Medicine DOI 10.1126/scitranslmed.abj4011 METHOD OF RESEARCH Randomized controlled/clinical trial SUBJECT OF RESEARCH People ARTICLE TITLE MR-guided focused ultrasound enhances delivery of Trastuzumab to Her2-positive brain metastases ARTICLE PUBLICATION DATE 13-Oct-2021 Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system. PrintEmail App Media Contact Wes Myhre Focused Ultrasound Foundation wmyhre@fusfoundation.org Office: 434-284-9285 More on this News Release World-first clinical trial demonstrates focused ultrasound can deliver antibody therapy to breast cancer metastases in the brain FOCUSED ULTRASOUND FOUNDATION JOURNAL Science Translational Medicine FUNDER DOI 10.1126/scitranslmed.abj4011 KEYWORDS BRAIN TUMORS BREAST CANCER BRAIN ULTRASOUND ANTIBODY THERAPY METASTASIS CANCER RESEARCH CLINICAL TRIALS BLOOD BRAIN BARRIER ORIGINAL SOURCE https://stm.sciencemag.org/lookup/do...nslmed.abj4011 EurekAlert! The Global Source for Science News AAAS - American Association for the Advancement of Science Copyright © 2021 by the American Association for the Advancement of Science (AAAS) facebook.com/EurekAlert @EurekAlert youtube.com/EurekAlert Help / FAQ Services Eligibility Guidelines Contact EurekAlert! Terms & Conditions Privacy Policy Disclaimer |
All times are GMT -7. The time now is 01:43 PM. |
Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021