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-   -   antioxidant which can stimulate breast cancer growth--caution! (https://her2support.org/vbulletin/showthread.php?t=36185)

Lani 10-19-2008 11:17 PM

antioxidant which can stimulate breast cancer growth--caution!
 
Eur J Cancer. 2008 Oct 14. [Epub ahead of print] Links

Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer.

Rossi C, Di Lena A, La Sorda R, Lattanzio R, Antolini L, Patassini C, Piantelli M, Alberti S.
Animal Care Unit, Consorzio Mario Negri Sud, S.M. Imbaro (Chieti), Italy.
OBJECTIVE: Breast and intestinal cancers chemoprevention would significantly impact on cancer care. Hence, we assessed the chemopreventive efficacy of the antioxidant lipoic acid (LA) in mice overexpressing a wild-type Her2/neu, as an animal model of breast cancer, and in APCmin mice for intestinal cancer. METHODS: Mice were randomised at weaning, and were treated with LA for lifetime. Tumour incidence, growth rate and histopathology were analysed on an individual tumour basis. RESULTS: LA efficiently chemoprevented tumour appearance in APCmin mice. Strikingly, though, LA doses, that were chemopreventive in APCmin mice (300mug/day), increased breast cancer growth in Her2/neu mice. Even in experimental groups, where LA overall reduced tumour risk (80mug/day), LA consistently stimulated the growth rate of established breast tumours. Breast and colon tumours incidence was unaffected by LA, indicating no significant impact of LA on tumour initiation and no protection from mutations driving tumour progression. CONCLUSIONS: Stimulation of breast cancer growth and inhibition of intestinal tumours by LA indicate that diverse growth control mechanisms are modulated by LA in different organs. Concern is raised about the use of LA for cancer chemoprevention.
PMID: 18926695

jhandley 10-20-2008 03:29 AM

interesting!
 
I have started taking Q10 with lipoic acid....it is cheaper than my other brand. In view of this study I will stop it and go back to the first one.
Jackie (down under)

CLTann 10-20-2008 04:45 PM

I just looked up my Q10 enzyme pill sold by Puritan Pride. It shows no lipoic acid present. I guess not all Q10 pills are the same.

'lizbeth 10-20-2008 06:27 PM

Is Alpha Lipoic Acid the same as the lipoic acid in the study?


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