Betulinic Acid (Birch, Chaga etc)
Supplement available: Herbal Extracts Plus
More info on Birch/Betulin: http://www.betulin.ca/betulin-products.html Chaga mushroom as source for Betulinic acid: http://www.chagatrade.ru/cchagamushroom.html, http://eartherbs.com/index.php?page=144& Int J Mol Sci. 2008 Jun;9(6):1096-107. Epub 2008 Jun 27. Betulinic Acid for cancer treatment and prevention. Fulda S. University Children's Hospital, Ulm, Germany. simone.fulda@uniklinik-ulm.de FREE TEXT Abstract Betulinic acid is a natural product with a range of biological effects, for example potent antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell death in cancer cells by triggering the mitochondrial pathway of apoptosis. In contrast to the cytotoxicity of betulinic acid against a variety of cancer types, normal cells and tissue are relatively resistant to betulinic acid, pointing to a therapeutic window. Compounds that exert a direct action on mitochondria present promising experimental cancer therapeutics, since they may trigger cell death under circumstances in which standard chemotherapeutics fail. Thus, mitochondrion-targeted agents such as betulinic acid hold great promise as a novel therapeutic strategy in the treatment of human cancers. PMID: 19325847 [PubMed]PMCID: PMC2658785Free PMC Article Quote:
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Betulinic acid, a natural compound with potent anticancer effects. Mullauer FB, Kessler JH, Medema JP. Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. purchase text Abstract New therapies using novel mechanisms to induce tumor cell death are needed with plants playing a crucial role as a source for potential anticancer compounds. One highly promising class of natural compounds are the triterpenoids with betulinic acid (BetA) as the most prominent representative. In-vitro studies have identified this agent as potently effective against a wide variety of cancer cells, also those derived from therapy-resistant and refractory tumors, whereas it has been found to be relatively nontoxic for healthy cells. In-vivo preclinically applied BetA showed some remarkable anticancer effects and a complete absence of systemic toxicity in rodents. BetA also cooperated with other therapies to induce tumor cell death and several potent derivatives have been discovered. Its antitumor activity has been related to its direct effects on mitochondria where it induces Bax/Bak-independent cytochrome-c release. PMID: 20075711 [PubMed - indexed for MEDLINE] Mol Nutr Food Res. 2009 Jan;53(1):140-6. Betulinic acid: a natural product with anticancer activity. Fulda S. University Children's Hospital, Ulm, Germany. simone.fulda@uniklinik-ulm.de http://www.ncbi.nlm.nih.gov/corehtml...ogo_120x27.gif Abstract Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of biological activities including potent antitumor properties. This anticancer activity has been linked to its ability to directly trigger mitochondrial membrane permeabilization, a central event in the apoptotic process that seals the cell's fate. In contrast to the potent cytotoxicity of BA against a variety of cancer types, nonmalignant cells and normal tissue remained relatively resistant to BA, indicating a therapeutic window. Since agents that exert a direct action on mitochondria may trigger cell death under circumstances in which standard chemotherapeutics fail, there is increasing interest to develop such compounds as experimental cancer therapeutics. Thus, mitochondrion-targeted agents such as BA hold great promise as a novel approach to bypass certain forms of drug resistance in human cancers. PMID: 19065582 [PubMed - indexed for MEDLINE] Strahlenther Onkol. 2010 Feb 22. [Epub ahead of print] Betulinic Acid a Radiosensitizer in Head and Neck Squamous Cell Carcinoma Cell Lines. Eder-Czembirek C, Erovic BM, Czembirek C, Brunner M, Selzer E, Pötter R, Thurnher D. Department of Cranio-, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria. http://www.ncbi.nlm.nih.gov/corehtml...ringerlink.gif Abstract BACKGROUND AND PURPOSE: : Betulinic acid, a pentacyclic triterpene, is a new cytotoxic compound active on melanoma, neuroblastoma, glioblastoma and head and neck squamous cell carcinoma (HNSCC) cells. In combination with irradiation it has been shown to have an additive effect on growth inhibition in melanoma cells. In this study, the radiosensitizing effect of betulinic acid on sequential irradiation was investigated in HNSCC cell lines. MATERIAL AND METHODS: : Two HNSCC cell lines, SCC9 and SCC25, were treated with increasing doses of betulinic acid and sequentially irradiated with a single boost of 4 Gy from a conventional radiation source. The cells were counted, the surviving fraction was determined, and colony-forming assays were performed. RESULTS: : It could be shown that betulinic acid alone inhibits cell survival, affects cell survival additively in combination with irradiation and decreases clonogenic survival in both cell lines when applied alone. CONCLUSION: : Betulinic acid could be a promising treatment agent in radioresistant head and neck cancer. A combination of betulinic acid with radiotherapy seems to be beneficial. PMID: 20339825 [PubMed - as supplied by publisher] Cancer Res. 2007 Mar 15;67(6):2816-23. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Chintharlapalli S, Papineni S, Ramaiah SK, Safe S. Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas 77843-4466, USA. Online TEXT FREE PDF Abstract Betulinic acid is a pentacyclic triterpene natural product initially identified as a melanoma-specific cytotoxic agent that exhibits low toxicity in animal models. Subsequent studies show that betulinic acid induces apoptosis and antiangiogenic responses in tumors derived from multiple tissues; however, the underlying mechanism of action is unknown. Using LNCaP prostate cancer cells as a model, we now show that betulinic acid decreases expression of vascular endothelial growth (VEGF) and the antiapoptotic protein survivin. The mechanism of these betulinic acid-induced antiangiogenic and proapoptotic responses in both LNCaP cells and in tumors is due to activation of selective proteasome-dependent degradation of the transcription factors specificity protein 1 (Sp1), Sp3, and Sp4, which regulate VEGF and survivin expression. Thus, betulinic acid acts as a novel anticancer agent through targeted degradation of Sp proteins that are highly overexpressed in tumors. PMID: 17363604 [PubMed - indexed for MEDLINE]Free Article Quote:
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http://www.freshpatents.com/Method-f...0060159783.php Quote:
http://www.docstoc.com/docs/46420400...Patent-6048847 Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):425-32. Epub 2009 Oct 12. Betulin elicits anti-cancer effects in tumour primary cultures and cell lines in vitro. Rzeski W, Stepulak A, Szymański M, Juszczak M, Grabarska A, Sifringer M, Kaczor J, Kandefer-Szerszeń M. Department of Virology and Immunology, Maria Curie-Sklodowska University, Lublin, Poland. rzeskiw@hektor.umcs.lublin.pl Purchase Text Abstract Betulin is a pentacyclic triterpene found in many plant species, among others, in white birch bark. The aim of the study was in vitro characterization of the anticancer activity of betulin in a range of human tumour cell lines (neuroblastoma, rhabdomyosarcoma-medulloblastoma, glioma, thyroid, breast, lung and colon carcinoma, leukaemia and multiple myeloma), and in primary tumour cultures isolated from patients (ovarian carcinoma, cervical carcinoma and glioblastoma multiforme). In this study, we demonstrated a remarkable anti-proliferative effect of betulin in all tested tumour cell cultures. Neuroblastoma (SK-N-AS) and colon carcinoma (HT-29) were the most sensitive to the anti-proliferative effect of betulin. Furthermore, betulin altered tumour cells morphology, decreased their motility and induced apoptotic cell death. These findings demonstrate the anti-cancer potential of betulin and suggest that they may be applied as an adjunctive measure in cancer treatment. PMID: 19821831 [PubMed - indexed for MEDLINE] |
Re: Betulinic Acid (Birch)
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Re: Betulinic Acid (Birch)
sounds very good!
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