Big news for Her2+!
 

Wanted to make sure you gals heard the news about the neratinib trials. 33% reduction in recurrence after Herceptin. Whoa this is big news! So you would do your full year of herceptin then another year of this new neratinib in the "extended adjuvant" setting. And it's completed its phase 3 trial?! I haven't been this excited about breast cancer news in a long time. It's usually: "we tested a new vaccine on a rat and it slowed cancer, now we have no funding to begin clinical testing. Try us again in 15 years." No this is something that could affect a lot of us. I've also read some encouraging things about this new drug (or is it a vaccine?) in the metastatic setting. This good to hear as my wife will be done with her herceptin/perjeta in December and I hear it may be available by Jan 2015. It's decent timing!

http://www.onclive.com/web-exclusive...t-Cancer-Study

Re: Big news for Her2+!
 

Thanks for posting this. It does look promising. I finish my full year of herceptin in August but I'm going to talk to my oncologist about this.

Re: Big news for Her2+!
 

There are also metastatic trials underway as well. Interesting that the stock for Puma (the biotech developing this) shot up 300% after this announcement. A lot of investors were shorting the stock (very common in biotech) because of the reports of diarrhea as a SE. LOL - almost all of our treatments do that!!!! I do the perjeta two step all the time. Also interesting that this might work better than herceptin. I wonder if it crosses the brain blood barrier? I think most nibs do. Looks like they are going for early approval, I wonder if it will be just for adjunct or also for metastatic.

Thanks for posting.

Re: Big news for Her2+!
 

I was on Neratinib (trial) and my experience was hell. Total hell. I've taken a lot of drugs and believe me, this is not one you'd wish to take. To boot, it did nothing for me. (But that's just me, I understand). An oncologist at Dana Farber thought it unlikely that this drug would even be approved in consideration of the MAJOR side effects. It's diarrhea times 20.

Karen