FISH ratio?
 

I just got the resuts back from the FISH test and the ratio was 4.31.

Is that bad?

Doug, the FISH test looks at how many copies of the HER2 gene are in the tissue sample; normally we have 2 copies of each gene, but us HER2+'s have extra. Your result shows that the sample they looked at had at 4+ copies. It means you are indeed highly positive for HER2 and if you need Herceptin down the road you would be eligible based on your FISH score. Here's a link to a page on the Test's and Treatments board which may help explain IHC(looks at how many HER2 receptors are on the surface of a cell) and FISH(goes into the DNA and looks at the genes).
I think it's a lot more complicated than I can explain!

FISH and IHC
http://www.her2support.org/her2fish.pdf