c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors
I just found it interesting that dogs apparently get HER2 breast cancers just like humans do. Maybe this will help scientists figure out more about Her2 sooner. Brazilian scientists report that "the morphology and biology of canine mammary malignant tumors are closely linked, just as in human breast cancer. Therefore, these results reinforce the idea that spontaneous canine mammary tumors can be used as a model to study the mammary carcinogenic process and may be relevant to the study of human breast cancer (36-38). The expression of immunoreactive cerbB- 2 in canine mammary tumors could be an important factor in canine mammary carcinogenesis. In humans, c-erbB-2 expression has been implicated in the initiation of breast cancer, and has even been used as an oncogene-targeted therapy (39,40). This fact opens up the possibility of using anti-c-erbB- 2 antibodies for the treatment of canine mammary tumors. In addition, further investigation is necessary to assess the value of the cerbB- 2 marker as a predictive factor in mammary cancer." |
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