Estradiol as treatment for ER+ breast cancer.
 

Another idea for those of us that are about to run out of option. Discuss this carefully with your oncologist, particularly in light of recent finding (last article) about the role of estrogen with respect to starting (instead of just fueling) breast cancer.

Revisiting Estrogen for the Treatment of Endocrine-Resistant Breast Cancer: Novel Therapeutic Approaches

https://pubmed.ncbi.nlm.nih.gov/37509308/

Estradiol as a Targeted, Late-Line Therapy in Metastatic Breast Cancer with Estrogen Receptor Amplification

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587405/

Alternating 17β-Estradiol and Aromatase Inhibitor Therapies in Postmenopausal Women With Advanced Endocrine-Resistant ER+ Breast Cancer

https://aacrjournals.org/clincancerr...dFrom=fulltext

Lower-dose (6 mg Daily) versus High-dose (30 mg Daily) Oral Estradiol Therapy of Hormone-receptor-positive, Aromatase-inhibitor-resistant Advanced Breast Cancer: A Randomized Phase 2 Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460383/

ERα-associated translocations underlie oncogene amplifications in breast cancer

https://www.nature.com/articles/s41586-023-06057-w