Meta Analysis of Ki-67
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Hopful,
Very interesting article, when I saw Dr. Slamon last April we discussed Ki-67 levels and he told then that this was a very important aspect of the tumor and that the level and the fact of having a postive Ki-67 was extremely important and that my dr. in New York had missed the boat in not addressing this aspect of my tumor. Interesting, thanks for posting this article. Jean |
Less omega six + more omega three = less Ki-67
RB http://www.leaonline.com/doi/abs/10....journalCode=nc Tumor prostaglandin E2 concentrations were reduced by feeding the lower LA level; further dose-dependent decreases occurred in the DHA dietary groups and were accompanied by reduced levels of 12- and 15-hydroxyeicosatetraenoic acids. These changes in eicosanoid biosynthesis may have been responsible for the observed decreases in cell proliferation, indicated by suppressed Ki-67 expression, and increases in apoptotic activity, as reflected in TdT-mediated dUTP nick end labeling immunohistochemical staining. |
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