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'lizbeth 10-29-2013 11:18 AM

MM-302 with Advanced Breast Cancer
 
Safety and Pharmacokinetic Study of MM-302 in Patients With Advanced Breast Cancer

NCT01304797
This study is a Phase 1 and pharmacologic open-label dose-escalation trial using a "3+3" design. Successive cohorts of three or more patients will be treated at escalating doses until a maximum tolerated dose is identified. Once the maximum tolerated dose is identified, an Expansion Cohort will be enrolled at that dose to further characterize safety and pharmacologic endpoints. Additional arms will be enrolled to explore the combination of MM-302 with trastuzumab or trastuzumab plus cyclophosphamide in patients with advanced HER2 positive breast cancer


http://www.clinicaltrials.gov/ct2/sh...=MM-302&rank=1

donocco 10-29-2013 12:40 PM

Re: MM-302 with Advanced Breast Cancer
 
I dont know if this is repetitive info but I did some quick
research on the drug. MM302 is a liposomal form of Doxorubicin (Adriamycin). The fatty liposome particles are coated with anti Her2neu protein particles, so the liposomes containing the Adriamycin go straight to the Her2Neu carrying breast cancer cells. Once inside the cancer cells, the liposome breaks up and the Adriamycin is released in the cancer cells hopefully killing it. The idea is to avoid the heart toxicity of Doxorubicin (Adriamycin) as the muscle cells in the heart have low levels of Her2Neu protein.

A possible dose might be 40mg per square meter once every 4 weeks. The main side effects seem to be constipation (53%), fatigue (69%) and decreased appetite (46%). Interestingly there was no mention of hand-foot syndrome (so far) which is a main side effect of Doxyl, the FDA approved liposomal Doxorubicin. Doxyl liposomes are not coated with anti-Her2Neu antibody and are less cancer cell specific.

Hope this helps a bit.

Paul

StephN 10-29-2013 01:05 PM

Re: MM-302 with Advanced Breast Cancer
 
Hey Paul!
Nice to see you and your helpful info here.

'lizbeth 10-29-2013 02:08 PM

Re: MM-302 with Advanced Breast Cancer
 
I love how this works. I find something interesting and post it. Then Paul pops up and explains it. Awesome.

Krysti 02-18-2014 02:28 PM

Re: MM-302 with Advanced Breast Cancer
 
I am on this trial - Arm 4 with cyclophosphamide/Herceptin/MM-302. Only second round, but doing well and excited about more Adriamycin as it worked well for me 9 years ago when I was first diagnosed out of the gate stage IV. I have had lung and 11 brain mets. Excited about the way it works, the drug delivery (like TDM-1 trial I was on) and that there is preliminary evidence by attaching a tracer to the drug that it goes to bone and brain (especially important in my case with 4 years of brain mets)...I will update and let you know how it goes!

'lizbeth 02-18-2014 07:42 PM

Re: MM-302 with Advanced Breast Cancer
 
Krysti,

Thank you for enrolling. I wish you the best. Keep us posted!


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