Association between the expression of hormone receptors and HER2/Neu in early breast
 

Association between the expression of hormone receptors and HER2/Neu in early breast cancer and overweight or obesity.

Abstract No:
e11552
Publication-only abstracts (abstract number preceded by an "e"), published in conjunction with the 2014 ASCO Annual Meeting but not presented at the Meeting, can be found online only.

Author(s): Eduardo Richardet, Martin Eduardo Richardet, Matias Molina, Matias Nicolas Cortes, Romina Brombin, Aldo Alejandro Riso, Pablo Companys, Luciana Paola Acosta, Patricia Hernandez; Instituto Oncologico de Cordoba, Cordoba, Argentina; Oncological Institute of Cordoba, Cordoba, Argentina
Abstract Disclosures

Abstract:

Background: In this paper we evaluate the association between overweight and obesity in patients with early-stage Breast Cancer in our population, and the presence of hormone receptors and Her 2 Neu. Methods: It is a retrospective study. A medical chart of 284 patients with early-stage Breast Cancer treated in our institution from 2005 to 2012 were evaluated. Obesity was defined as BMI greater than 30, overweight as a BMI between 25 and 29, and normal weight BMI since 18 to 24. Results: The median age was 62, 23 years. Follow-up was 53 months. The average BMI was 25.92. 39% of patients had normal weight, 36% overweight and 24% obesity. 78% of patients had positive hormone receptors, 14.78% were Her 2 neu positive and 11% triple negative. In this study we found a statistically significant association between patients with obesity or overweight and the presence of hormone receptor-positive (p = 0.001) and Her 2 Neu positive (p = 0.001). Conclusions: In our population, obesity / overweight were significantly associated with the presence of hormone receptors and Her 2 Neu in early breast cancer.