Good news for coffe drinkers on Tamoxifen
 

Cancer Causes Control. 2013 Feb 15. [Epub ahead of print]
Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.

Simonsson M, Söderlind V, Henningson M, Hjertberg M, Rose C, Ingvar C, Jernström H.
Source

Department of Oncology, Clinical Sciences, Lund, Lund University, Barngatan 2B, 22185, Lund, Sweden.

Abstract

PURPOSE:

Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investigate the impact of coffee consumption on tumor characteristics and risk for early events in relation to breast cancer treatment and CYP1A2 and CYP2C8 genotypes.
METHODS:

Questionnaires regarding lifestyle were completed preoperatively by 634 patients in southern Sweden. CYP1A2*1F and CYP2C8*3 were genotyped. Clinical data and tumor characteristics were obtained from patients' charts, population registries, and pathology reports. Coffee consumption was categorized as low (0-1 cups/day), moderate (2-4 cups/day), or high (5+ cups/day).
RESULTS:

The proportion of estrogen receptor negative (ER-) tumors increased with increasing coffee consumption (p (trend) = 0.042). Moderate to high consumption was associated with lower frequency of discordant receptor status (ER + PgR-) OR 0.38 (0.23-0.63) compared to low consumption. Median follow-up time was 4.92 (IQR 3.01-6.42) years. Tamoxifen-treated patients with ER+ tumors (n = 310) who consumed two or more cups/day had significantly decreased risk for early events compared to patients with low consumption, adjusted HR 0.40 (0.19-0.83). Low consumption combined with at least one CYP1A2*1F C-allele (n = 35) or CYP2C8*3 (n = 13) was associated with a high risk for early events in tamoxifen-treated patients compared to other tamoxifen-treated patients, adjusted HRs 3.49 (1.54-7.91) and 6.15 (2.46-15.36), respectively.
CONCLUSION:

Moderate to high coffee consumption was associated with significantly decreased risk for early events in tamoxifen-treated patients and modified hormone receptor status. If confirmed, new recommendations regarding coffee consumption during tamoxifen treatment may be warranted.


PMID:23412805 [PubMed - as supplied by publisher]

Re: Good news for coffe drinkers on Tamoxifen
 

Hey Bird!

Where ya been? Thanks for this article. I wish Rich would see it! He always gave me a hard time about my coffee consumption. Ha! Soon they will say red wine and beer reduce risk!

Thanks for post and glad to "hear" from you again. We need our guys on this site!

Re: Good news for coffe drinkers on Tamoxifen
 

Laurel--Thanks for asking. You are correct that I haven't visited this site in several months, but not because anything sinister going on with my bc. As a matter of fact I got to feeling so good about it that I had my port removed 3 months ago and vowed to not look back. I'm now approaching 4 years since diagnosis and planning to be on the way to many more such anniversaries enjoying my coffee . ---bird

Re: Good news for coffe drinkers on Tamoxifen
 

Hi Rarebird,


Glad to hear from you!

Congratulations on your upcoming fourth year cancer free anniversary!!

Take care, don't be a stranger, keep in touch, please.

Adriana

Re: Good news for coffe drinkers on Tamoxifen
 

Adriana--Thanks for noting my presence and giving me another reason to review your incredible cancer-bio. That 20 years+ record of yours is just what I needed to give my wife (and me) encouragement that there are many options for us to pursue should recurrence be in the future for me. I hope you continue for another 20 years and more beating back your cancer. I think you will.---bird