Mixed reviews on scans while on tdm-1
 

Not the news I was hoping for, but my scans showed improvement on nodes inside the body, but progression on the soft tissue skin mets by the neck nodes....due to the eap trial reqs, I was booted off. I began a brand new chemotherapy, eribulen this week on Monday...I am the first to get it at my hospital....I will be getting it with Herceptin. felt a little nauseous the first few days, but am in San Antonio with the her2 support group, trying to learn all I can. Talked with the easai reps that make this drug, marketed under the name halaven....hoping it will be a success for me, or at the least buy me time until the magic drug comes along....pertuzamab is getting great reviews here...as a combo drug therapy.

Re: Mixed reviews on scans while on tdm-1
 

Good luck -you are a real trail blazer. Enjoy the conference and I hope the treatment works a treat. Look forward to hearing.
Trish

Re: Mixed reviews on scans while on tdm-1
 

Sheila, I think there was a post somewhere (maybe on this site) about Halaven being the new wonder drug for skin mets. Really hope it works for you. I have skin mets to the chest, looks like a mini red cauliflour, cant seem to get rid of it. I hope you will really be a trailblazer and wipe the buggers out completely. Best wishes.

Re: Mixed reviews on scans while on tdm-1
 

Sheila, I hope that your feeling yucky means that the new drug is doing it's damage to those skins mets. ma

Re: Mixed reviews on scans while on tdm-1
 

Re: Mixed reviews on scans while on tdm-1
 

Shelia,
I was so hoping the T-DM1 was going to be your magic bullet...as I'm sure you were too. Darn it all! Here's to the new drug kicking some cancer butt...including those misrable little skin mets. Shelia, your truly an inspriation...one tough gal. The strength you find to keep going, especially when starting a new chemo regimen boggles my mind! You really amaze me. If you could bottle just a little of what you have and send it my way I would be good to go. :) Keeping you in my thoughts and prayers that this new drug does the job.

Chelee

Re: Mixed reviews on scans while on tdm-1
 

New year, new meds, new hope...

Re: Mixed reviews on scans while on tdm-1
 

PinkGirl,TipToe is herein San Antonio...pictures to follow when I get home

Re: Mixed reviews on scans while on tdm-1
 

Good luck with your new treatment and posting
about the other drug. Take care and enjoy the
trip.
patb

Re: Mixed reviews on scans while on tdm-1
 

I hope the Eribulen helps. Let us know. I posted some information about drugs for skin mets in the clinical trials thread awhile back. One post was about the University of Washington Tumor Group study using Abraxane and Immiquimod cream and I think the other one was about Pazopanib and Tykerb. I am hearing good things about the Marianne Trial for T DM1 which combines it with another drug. Maybe you can get that later.
It also seems that her2 breast cancer was discussed alot at the San Antonio Breast Cancer Symposium
http://media.curetoday.com/sabcs2010/
Since you are there perhaps you can get some transcripts about those discussions to share with your oncologist after you return home. Take care.
Take good care of yourself. I have my fingers crossed for you.

Re: Mixed reviews on scans while on tdm-1
 

Yes, third arm of Marianne trial, T-DM1 plus Pertuzumab could be a very effective treatment.
Immunogen Inc reported on T-DM1 Plus Pertuzumab for First-Line HER2+ mBC. The data reported today from SABCS are from a Phase Ib/II clinical trial conducted by Roche to assess T-DM1 used in combination with pertuzumab to treat HER2+ mBC. The study enrolled 21 patients who had not received prior systemic anticancer therapy for metastatic disease. Among these patients, 57.1% had a confirmed objective response to treatment with T-DM1 plus pertuzumab.


All of these patients had received anticancer agents prior to their development of metastatic disease (e.g., as adjuvant therapy). Eighty-six percent (86%) of these patients had received Herceptin® (trastuzumab), 71% had received a taxane, and 62% had received an anthracycline before being diagnosed with metastatic disease.

Re: Mixed reviews on scans while on tdm-1
 

Sheila, I wish you the best on the new treatment and continued improvement. Hey girlfriend....saw the article about you in the Amoena magazine a few days ago while I was picking up a "breast product"....ha! You are amazing! Ceesun

Re: Mixed reviews on scans while on tdm-1
 

Sheila's neck did show noticeable improvement during our days together in San Antonio.

She got stuck there for another 2 days due to the snow covering the Chicago area, but she should be there by now.

The booth for the company that makes the new drug Halaven was very close to our booth. The reps there were happy to meet someone who was actually taking their drug!

Re: Mixed reviews on scans while on tdm-1
 

Home in time to receive treatment #2 of Eribulen (Halaven)..my nodes and skin mets are disappearing before my eyes...after 2 treatments! Slight nausea...compazine is working for that...and the hair is starting to tingle, so I feel baldness is in my future, as expected.....but with the response on the neck nodes/skin mets....who cares about hair!!!!

Re: Mixed reviews on scans while on tdm-1
 

Sheila,
So glad to hear the nodes are melting!!

I hope you enjoyed your time with the rest of the Her2 contingent in San Antonio.

Lori

Re: Mixed reviews on scans while on tdm-1
 

Wow!! Sheila, congratulations. I'm going to request that drug next time I see my oncologist.

Re: Mixed reviews on scans while on tdm-1
 

I'm coming in a little late here Sheila but so glad to read the good news , sounds like this treatment is your magic bullet!!

Re: Mixed reviews on scans while on tdm-1
 

Sheila, this is wonderful news. I hope this time every single node and skin met will vanish. You are such a fighter. I would like you so much to have a real cure. This news makes me so happy in the middle of my own mess. Love and Hugs. Michka

Re: Mixed reviews on scans while on tdm-1
 

Sheila,

This is great news!

Joan

Re: Mixed reviews on scans while on tdm-1
 

Wonderful news Shiela! I am very thrilled for this new drug.

Julie