Omega-6 fatty acids hasten growth of prostate cancer cells
Although prostate cancer cells were studied here, this is something RB, Lani and others have posted about continuously and something I also find very important.
Regards, Becky Omega-6 fatty acids hasten growth of prostate cancer cells Posted: February 10, 2006 http://www.asco.org/portal/beans/reu...ages/clear.gif NEW YORK (Reuters Health) - Adding arachidonic acid, an omega-6 fatty acid, to culture media causes prostate cancer cells to grow twice as fast as usual, according to a report in the February 1st issue of Cancer Research. "Investigating the reasons for this rapid growth, we discovered that the omega-6 was turning on a dozen inflammatory genes that are known to be important in cancer," lead author Dr. Millie Hughes-Fulford, from the San Francisco VA Medical Center, said in a statement. Further analysis indicated that arachidonic acid was activating these genes through a PI3-kinase pathway known to play a key role in the pathogenesis of cancer. Adding an NSAID or a PI3-kinase inhibitor to the culture media blocked the arachidonic acid-induced proliferation of prostate cancer cells, the findings indicate. In light of the current findings, Dr. Hughes-Fulford said she now avoids cooking with corn oil, which is known to be high in omega-6 fatty acids. "I'm not a physician, and do not tell people how to eat, but I can tell you what I do in my own home. I use only canola oil and olive oil." http://www.asco.org/portal/beans/reu...ages/clear.gif |
It is good to see that the impact of excess omega six is begining to be looked at in trials.
I have previously posted that in one trial a host of gene and protein expressions are up and down graded by omega six in skeltal muscle in mice. Endothelin B receptor (Ednrb) and CD40L which are amongst them unpregulated by a diet high in omega six them by a factor of TEN. It is interesting that inflamatory genes were stated to be important in cancer. Thank you interesting post. RB |
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