EUREKA !(?) from the Weitzman Institute--real Hope!!
[Cancer Research 66, 5371-5378, May 15, 2006]
© 2006 American Association for Cancer Research Experimental Therapeutics, Molecular Targets, and Chemical Biology Inhibition of Tumor Growth and Elimination of Multiple Metastases in Human Prostate and Breast Xenografts by Systemic Inoculation of a Host Defense–Like Lytic Peptide Niv Papo1, Dalia Seger2, Arik Makovitzki1, Vyacheslav Kalchenko3, Zelig Eshhar4, Hadassa Degani2 and Yechiel Shai1 Departments of 1 Biological Chemistry, 2 Biological Regulation, 3 Veterinary Resources, and 4 Immunology, The Weizmann Institute of Science, Rehovot, Israel Requests for reprints: Yechiel Shai, Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel. Phone: 972-8-934-2711; Fax: 972-8-934-4112; E-mail: Yechiel.Shai@weizmann.ac.il. We report on a short host defense–like peptide that targets and arrests the growth of aggressive and hormone-resistant primary human prostate and breast tumors and prevents their experimental and spontaneous metastases, respectively, when systemically inoculated to immuodeficient mice. These effects are correlated with increased necrosis of the tumor cells and a significant decrease in the overall tumor microvessel density, as well as newly formed capillary tubes and prostate-specific antigen secretion (in prostate tumors). Growth inhibition of orthotopic tumors derived from stably transfected highly fluorescent human breast cancer cells and prevention of their naturally occurring metastases were visualized in real time by using noninvasive whole-body optical imaging. The exclusive selectivity of the peptide towards cancer derives from its specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization. These data indicate that membrane disruption can provide a therapeutic means of inhibiting tumor growth and preventing metastases of various cancers. (Cancer Res 2006; 66(10): 5371-8) |
Interesting stuff! Thank you Lani.
|
Thank you
Lani,
That was a great find. Thank you very much. Not much in the way of research gets me excited any more, but when you talk about selective disruption of cytoplasmic membranes, my juices really get flowing. I will try to follow this closely and see if it is discussed on any of my cellular research websites. Tom |
All times are GMT -7. The time now is 01:21 PM. |
Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021