Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast
 

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer.

Phase 1b clinical trial results published in*JAMA Oncology*show promise for the combination of tucatinib (formerly ONT-380) with T-DM1 against heavily pretreated HER2-positive breast cancer. Of 57 patients treated, 48 percent responded to the combination, with cancer control of median 8.2 months. Importantly, tucatinib acted against brain metastases stemming from HER2+ breast cancer, a major cause of mortality from the disease.

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