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-   -   Dogs get HER2 breast cancer too! (https://her2support.org/vbulletin/showthread.php?t=19450)

Christine MH 02-05-2005 02:35 PM

c-erbB-2 expression and nuclear pleomorphism in canine mammary tumors

I just found it interesting that dogs apparently get HER2 breast cancers just like humans do. Maybe this will help scientists figure out more about Her2 sooner.

Brazilian scientists report that
"the morphology and biology of canine mammary
malignant tumors are closely linked, just as
in human breast cancer. Therefore, these
results reinforce the idea that spontaneous
canine mammary tumors can be used as a
model to study the mammary carcinogenic
process and may be relevant to the study of
human breast cancer (36-38).
The expression of immunoreactive cerbB-
2 in canine mammary tumors could be
an important factor in canine mammary carcinogenesis.
In humans, c-erbB-2 expression
has been implicated in the initiation of
breast cancer, and has even been used as an
oncogene-targeted therapy (39,40). This fact
opens up the possibility of using anti-c-erbB-
2 antibodies for the treatment of canine mammary
tumors. In addition, further investigation
is necessary to assess the value of the cerbB-
2 marker as a predictive factor in mammary
cancer."


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