Staggered Cancer Drug Delivery Better Than All In One Go
 

The fact that treating cancer patients with multiple drugs often results in better outcomes than a single drug treatment is long been known amongst the medical profession. However, a MIT study published in the May 11 issue of Cell has just demonstrated that the order and timing of administering drugs may also have a dramatic impact...

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Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

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Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Role on when they do! At present it seems a one size fits all!
Ellie

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

The is similar to the principle achieved with functional profiling with Gemzar + Carboplatin.

The most probable mechanism for the "synergy" between Gemzar + Carboplatin is Gemzar inhibition of repair of platinum/DNA adducts. What this means is that platinum-resistant tumor cells "cut out" the damaged DNA (to which the platinum is attached) in the same way that a railroad company repairs damage sections of rail track. The railroad company lays down new track. Platinum-resistant tumor cells do the same thing, and Gemzar interferes with this process.

You want to administer the Gemzar first (to have it on board to inhibit the repair process). Then, you want to administer Carboplatin shortly thereafter. In addition, you don't want to give either Gemzar or Carboplatin by itself on any days of the cycle. This doesn't take advantage of the "synergy" between the drugs and, in many cases, will just increase toxicity.

If they can lower the dosage of Gemzar and not have that break after week three, the better. The "low-dose" protocol can have both anti-tumor and anti-vascular effects on various tumors, depending on the individual cancer patient.

Dr. Nagourney had found the availability of comparably mild agents, like the "low-dose" Gemzar + Platinum doublet, can be safely continued for long periods of time. He was the first to report that in the original PARP inhibitor clinical trial with Carboplatin + Gemzar, that even a lower starting dose (from 1000mg/ml2 to 800mg/ml2) resulted in significant toxicity and he suggested 600mg/ml2.

It's not the drugs per se, but rather how they are selected, that has changed outcomes so dramatically. This is about the biggest advantage of the functional profiling platform. The more they bring this out the more functional profiling shines.

http://cancerfocus.org/forum/showthread.php?t=3346

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

How long is shortly?

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Being that you don't want to give either Gemzar or Carboplatin by itself on any days of the cycle, that would mean shortly thereafter on the same day, to take advantage of the synergy between the drugs, without increasing toxicity.

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Therefore.."How long is shortly?"

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Within that clinical visit.

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

So...translating to real world..morning infusion followed by afteernoon infusion of secondary?

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Whatever would knock your socks off!

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Only thing that knocks my socks off are strategies prone to working.

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

You can always rely on the trial-and-error physician's choice strategy. Best guesstimate.

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Cop out response, Greg. ;)

What's the interval in the estimation you promote?

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

I'll repeat it once more. Being that you don't want to give either Gemzar or Carboplatin by itself on any days of the cycle, that would mean shortly thereafter on the same day, to take advantage of the synergy between the drugs, without increasing toxicity.

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Same day? What portion of the 24hr schedule?

Sorry..can't promote Devil in the details while remaining vague. I have VERY strong interest in Chronotherapy(Levi, Hruschesky)..unfortunately the tools seem admittedly crude at this stage.
Meaning...details matter outside Oca and Gemzar. Especially in terms of obtainable infusion schedules...some being obtainable by gross replicative standard style infusion approaches..or..via limited availability chronometric/programmatic infusion via clinics with programmable pumps like at Block center.

Re: Staggered Cancer Drug Delivery Better Than All In One Go
 

Rich

I'm not a chemotherapist. I don't know (or remember anymore) the intimate details of when the gas station serves business during the day. All I can tell you (a.k.a. the Gemzar + Carboplatin protocol) is that it suggests shortly after on the same day.

Yes, I do know about the "circadian" issue being talked a lot in medical oncology, and the circadian biology applying timing for effective administration of medicines (biological temporal rhythms), called chronobiology.

Greg