weird pubmed du jour
 

Anal Chim Acta. 2010 Mar 3;662(1):82-89. Epub 2010 Jan 11.
Evaluation of the feasibility of the electronic tongue as a rapid analytical tool for wine age prediction and quantification of the organic acids and phenolic compounds. The case-study of Madeira wine.

Rudnitskaya A, Rocha SM, Legin A, Pereira V, Marques JC.
CESAM/Chemistry Department, University of Aveiro, Aveiro 3810-193, Portugal; Chemistry Department, St. Petersburg University, St. Petersburg 199034, Russia.
A set of fourteen Madeira wines comprising wines produced from four Vitis vinifera L. varieties (Bual, Malvasia, Verdelho and Tinta Negra Mole) that were 3, 6, 10 and 17 years old was analysed using HPLC and an electronic tongue (ET) multisensor system. Concentrations of 24 organic acids, phenolic and furanic compounds were determined by HPLC. The ET consisting of 26 potentiometric chemical sensors with plasticized PVC and chalcogenide glass membranes was used. Significance of the effects of age and variety on the ET response and wine composition with respect to the organic acids, phenolics and furanic derivatives were evaluated using ANOVA-Simultaneous Component Analysis (ASCA). Significance of the effects was estimated using a permutation test (1000 permutations). It was found that effects of age, grape variety and their interaction were significant for the HPLC data set and only the effect of age was significant for the ET data. Calibration models of the HPLC and ET data with respect to the wine age and of the ET data with respect to the concentration of the organic acids and phenolics were calculated using PLS1 regression. Models were validated using cross-validation. It was possible to predict wine age from HPLC and ET data with the accuracy in cross-validation of 2.6 and 1.8 years respectively. The ET was capable of detecting the following components (mean relative error in cross-validation is shown in the parentheses): tartaric (8%), citric (5%), formic (12%), protocatehuic (5%), vanillic (18%) and sinapic (14%) acids, catechin (6%), vanillin (12%) and trans-resveratrol (5%). The ET capability of predicting Madeira wine age with good accuracy (1.8 years) as well as quantify of some organic acids and phenolic compounds was demonstrated. Copyright © 2010 Elsevier B.V. All rights reserved.

PMID: 20152269 [PubMed - as supplied by publisher]

Re: weird pubmed du jour
 

Breast Cancer Res. 2010 Feb 8;12(1):303. [Epub ahead of print]
Estrogen receptor action in three dimensions - looping the loop.

Theodorou V, Carroll JS.
Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, CB2 0RE, UK. jason.carroll@cancer.org.uk.
ABSTRACT: Due to advances in genomic technologies, our understanding of estrogen receptor (ER)-mediated transcription in breast cancer cells has evolved significantly in recent years. Genome-wide mapping experiments revealed thousands of ER-binding events, but linking them to the target genes has been an ongoing struggle. A recent paper describes a new technique, called ChIA-PET (chromatin interaction analysis using paired-end tag sequencing), that can directly address these questions. ChIA-PET is an unbiased approach for simultaneously identifying all genome-wide binding.

http://www.walyou.com/blog/wp-conten...d-chia-pet.jpg

Re: weird pubmed du jour
 

Is that you in the background, Rich? What are you growing?

Re: weird pubmed du jour
 

Just read the 2nd post. Wow, ChIA-PET!
Who would have guessed!!
Love & hugs,
Marlys

Re: weird pubmed du jour
 

Re: weird pubmed du jour