~Rich66~Update on Mom If You have A Moment
Hey Rich, thinking about Mom and wondering how she is making out. I have been very busy lately but I have been following her journey the best I can. Keep doing what you are doing, you are a wonderful son and caregiver. Keeping Mom on my mind and sending her a cyber hug and positive thoughts her way!! If you get a moment please update us all>>Believe51
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Thank you! Awaiting path er and her2 status of biopsy and meeting with local onc Thursday (18th) to hear options, meeting with Dr. Cobleigh in Chicago on the 25th. Meanwhile trying to understand current options for liver mets status as well as promising pipeline developments. Any thoughts always welcome. Thanks again!
PS: Does yellowish bm mean anything? |
Rich,
Please check your private message and e-mail. Donna |
Having labs drawn tomorrow. Seems like possible jaundice. Anyone have this with liver mets?
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Hi -
Jaundice is not a good sign. I did not get to that point with my liver mets, but Esther and a couple of other members here did have jaundice. If it is jaundice, your Mom needs immediate treatment. She should not wait until the 25th to see Dr. Cobleigh. If it is jaundice, call this onc and get your Mom in ASAP. |
Hi -
Please post on the lab results and the possible jaundice when you have them. |
Onc left message while mom was out saying, pathology was in (no details) bilirubin was up "slightly", she would call tomorrow..and that Thursday consult would be start date for treatment(no details). A bit concerned..just a few hours to decide? No second opinion? !!!!!
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Is this normal?
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Her 2 came at "low end of high" 1.8 FISH at state lab. Re-doing part of test. Local onc not considerng it her2 pos. Offering Xeloda. Suggesting start tomorow
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Rich
Thanks for the wonderful updates of 'pieced' information as you get it. I will be thinking of her as she embarks on this new chemo regime. This is a great drug and has proven effective in so many others, I am praying the same for Mom.
And you Rich, have grown so very much since you have found us here. Your love, support and devotion for Mom shines so bright. You have researched and gathered ammo here and on other reputable sites to guide your Mother into her recovery. So here is to you both: May you find the missing piece of her puzzle and may Mom have a fair fight to beat up those nasties.>>Believe51 PS.....'fair fight' seems so inappropriate being used in cancer-talk....none of this is fair to anyone who has this damn illness. |
This feels very bad right now. The local onc actually said that if this doesn't work, there may be no treatment to pursue. This thought seems to be driven by a rise in bilirubin. 1.9 on some scale with normal limit of 1 that is different from what the onc usually sees. But the same lab had some sort of problem with another part of the blood test..I think the whole blood test should be redone elsewhere. And the borderline FISH makes me think that should be redone in another lab for comparison. Have e-mailed the onc about this. This is happening so fast.
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hot off the press(with comments)
1: J Clin Oncol. 2008 Sep 15. [Epub ahead of print]
PMID: 18794539 [PubMed - as supplied by publisheMetronomic Cyclophosphamide and Capecitabine Combined With Bevacizumab in Advanced Breast Cancer. Dellapasqua S, Bertolini F, Bagnardi V, Campagnoli E, Scarano E, Torrisi R, Shaked Y, Mancuso P, Goldhirsch A, Rocca A, Pietri E, Colleoni M. Medical Senology Research Unit and Division of Medical Oncology, Department of Medicine; Division of Hematology-Oncology, Department of Medicine; and Division of Epidemiology and Biostatistics, European Institute of Oncology; Department of Statistics, University of Milan-Bicocca, Milan, Italy; Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; and Oncology Institute of Southern Switzerland, Bellinzona and Lugano, Switzerland. PURPOSE: Metronomic chemotherapy has shown efficacy in patients with metastatic breast cancer. When used in association with targeted antiangiogenic drugs, it was more active than metronomic therapy alone in preclinical and clinical studies. PATIENTS AND METHODS: Patients with advanced breast cancer were candidates to receive metronomic oral capecitabine (500 mg thrice daily) and cyclophosphamide (50 mg daily) plus bevacizumab (10 mg/kg every 2 weeks). RESULTS: In 46 assessable patients, we observed one complete response (CR; 2%), 21 partial responses (PR; 46%), 19 patients (41%) with stable disease (SD), and five patients (11%) with progressive disease, for an overall response rate of 48% (95% CI, 33% to 63%). Additional long-term disease stabilization (SD >/= 24 weeks) occurred in eight patients, for an overall clinical benefit (CR + PR + SD >/= 24 weeks) of 68% (95% CI, 51% to 81%). Median time to progression was 42 weeks (95% CI, 26 to 72 weeks). Toxicity was generally mild. Grade 3 or 4 nonhematologic adverse effects included hypertension (n = 8), transaminitis (n = 2), and nausea/vomiting (n = 2). Higher baseline circulating endothelial cells (CECs) were correlated with overall response (P = .02), clinical benefit (P = .01), and improved progression-free survival (P = .04). CONCLUSION: Treatment with metronomic capecitabine and cyclophosphamide in combination with bevacizumab was effective in advanced breast cancer and was minimally toxic. The number of baseline CECs significantly correlated with response and outcome, therefore supporting further studies on this surrogate marker for the selection of patients to be candidates for antiangiogenic treatments. This was for her2- bc (for her2+ they combined metronomic w herceptin) Virtually all trials want normal liver functions as they do not want to cause liver failure/unacceptable toxicity caused by their "experimental combination" Let's hope you mom's LFT problems were due to a virus or other transient, correctible cause. This happened to my dad about three weeks ago. His LFTs were 100 times normal and it was assumed it was due to one of his two cancers (one of which is already known to have metastasized to his liver). But two weeks later his LFTs were normal --his doctor ordered antibody titers for cytomegalovirus before going on vacation. It is unclear to me if they were ever done, or how they came out, but as my fathers LFTs went back to normal, it became a moot point. |
Lani,
Does this study have implications for non-study treatment? The bilirubin will be retested tomorrow. I have asked that the FISH be redone since it is borderline "low side of high". What I have read labels that as "equivocal" results. Any thoughts on Xeloda as monotherapy vs with Taxane? |
Rich -
Look up TriciaK on this site. She has heart trouble and DID take Herceptin for her mets. She has been NED for a few years now. They say that mets grow more slowly in the elderly, so these people do not often get the immediate attention the younger patients get. The recheck is the best idea, but for the FISH test it takes longer than the usual labs. I have a friend in her 70's who is back on Xeloda for the 2nd time and doing fine with it. The only Taxane this friend took was Abraxane and it was definitely tougher for her. Although the Abraxane shut down her mets when the Xeloda was no longer effective. |
Rich
I was on Xeloda for over a year with great success and very little side effects...mine was with Herceptin. The beauty is that it is in pill form...you can take it at home. Good luck tomorrow with your Mom. |
there is a new test approved to recheck equivocal FISH results
(perhaps even two)
]an article about New breast-cancer tests perhaps being too costly cited TWO new diagnostic tests which could further hospitals' reach into the world of genetic testing--it's unclear whether the new technologies for detecting a breast-cancer gene will be better options financially than existing tests or improve clinical outcomes. Existing tests for her 2 to determine if a patient is a candidate for herceptin " are thought to be sometimes unreliable and can be expensive. By contrast, manufacturers of the newer HER2 tests--Invitrogen Corp.'s SpotLight HER2 Chromogenic In Situ Hybridization, or CISH, test and Monogram Biosciences' HERmark test--say their versions are either a better predictor of Herceptin-treatment candidates or more affordable and equally as accurate. The new offerings are competing to siphon market share from Abbott Molecular's existing Fluorescence In Situ Hybridization, or FISH, technology--currently considered the gold standard for HER2-gene testing--and the Denmark-based diagnostics company Dako's HercepTest- -currently used as a front-line test for the HER2 gene. Despite some promising claims regarding the tests, hospitals are likely to take a go-slow approach toward adopting them. The maker of the Spot-Light CISH test is targeting current users of Abbott's FISH test. Marketed under the name PathVysion, FISH probes breast tumors for HER2 DNA then uses a florescent microscope to check the sample for overproduction of HER2 genes. The test is considered the more accurate of the two established diagnostic technologies, but FISH testing does present challenges to providers. "It requires more time, is more expensive and requires a special florescent microscope" when compared to the older HercepTest, said Brian Leyland-Jones, director of the Emory Winship Cancer Institute. CISH operates without the need for a fluorescent microscope. As a result, providers are anxious to see whether CISH could be a clinically sound, more affordable substitute for FISH, Leyland-Jones added, noting research suggests it might. According to a multicenter study conducted by researchers at the 512-bed University of Texas M.D. Anderson Cancer Center ill Houston, the University of Tampere in Finland and Invitrogen's pathology department in Camarillo, Calif., FISH and CISH achieved nearly identical results in identifying candidates for Herceptin treatment. For the study, pathologists ran comparison tests on 226 breast-cancer specimens, and found a 99% rate of agreement. According to Bill Sweet, Invitrogen's director of product management, the CISH costs about $70 per kit compared with $145 per kit for FISH, adding that hospitals can bill for CISH under existing FISH CPT codes. Medicare currently reimburses at a rate of $169 for FISH testing. Meanwhile, at $3,350 per test, the new HERmark test is significantly more expensive than any of its competitors. Monogram is wagering, however, that the accuracy of HERmark will make it an appealing option. Like HercepTest, HERmark looks for HER2 proteins. But HERmark is able to take a precise measure of the level of the protein where HercepTest relies on a pathologist's view of a specimen to estimate the level. "The thought is, HERmark may be more accurate (than the three other tests) in determining whether a patient will benefit from treatment with Herceptin because Herceptin targets the HER2 protein and not the gene," explained Edith Perez, chairwoman of the Mayo Clinic's breast cancer program. Mayo provided Monogram Bioscience with tumor specimens to be used in additional studies of the diagnostic test, but Perez said that she has received no compensation for participating in the research work. Monogram Bioscience Chief Financial Officer Alfred Merriweather said that reimbursement shouldn't be an issue for providers, as HERmark is a proprietary diagnostic test. As a result, Invitrogen, not hospitals or patients, will incur the responsibility for seeking reimbursement from payers. Still, at $3,350 per test, HERmark's cost far outpaces insurers' current rates of reimbursement for HER2 testing. " |
Bilirubin recheck still at 1.8..slightly elevated.
Her2 is being rechecked here by IHC..the known to be inferior test. Didn't like it when I pointed this out. I had sent her these links previously: http://www.medscape.com/viewarticle/562042 http://www.medscape.com/viewarticle/570997_4 "For these tumors, counting additional cells did not change the HER2 status because all showed equivocal amplification. On repeated FISH, the average number of cells counted was 40 (range, 30-60 cells). It seems from our study that repeated FISH on a larger tumor section is more helpful than counting additional cells on an equivocally amplified sample." Neither article discusses using IHC to recheck. Asked to have it sent to Mayo for independent FISH. In other words still in "equivocal" territory regarding 1.8 FISH and the Her2 issue altogether. Visit emphasis was on Xeloda...maybe combined with AI. I brought up Taxol and she said not good with Xeloda...single agent approach better because lower toxicity. I mentioned Avastin and suddenly she said could do Avastin and Taxol. Maybe because of FDA fast track? I asked if it was more effective than xeloda and she said no one knows..never compared. But...1!&$! Chest x-ray shows 2cm mass in lung... Chest CT and bone scan will be done early October. Trying to determine if she should take "something" before 2nd opinion next Thursday. Only drawback would be trial exclusion..maybe trials would take to long to enter/get approval anyway...right? Doc here thinks it's probably ok..but it all makes me nervous and a bit crazy. I put a call into Cobleigh's nurse and hopefully the Dr. will call us tomorrow for guidance and/or earlier appointment for 2nd opinion. Hard to know what's prudent.......... |
Getting kicked out of library.
After putting 2 oncs together... Wednesday 9am Mom starts Taxol/carbo/Hercep(in case FISH becomes positive) Please give thoughts, advise regarding side effects etc. Wondering about drugs to support immune and Iron. |
I sure don't know enough about this to offer advice..but wanted to wish you the best and let you know I'm thinking of you and your mom.
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Any comments on typicalside effects..especially day of first cycle?We are supposed to travel afterwards to Chicago (2.5 hr drive)
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