Researchers at The University of Texas M. D. Anderson Cancer Center now have evidence that receptors found on tumors that were believed to function only on the surface of cells can actually switch on genes inside a cell's nucleus thus promoting cancer development in two distinct ways.
They specifically found that HER-2 cell surface receptors known to promote breast and other cancers when they allow too many growth signals to enter a cell can actually travel into the nucleus and turn on a variety of genes including COX-2 which also is associated with carcinogenesis.

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