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-   -   Vaccine Therapy in Combination With Rintatolimod and/or Sargramostim in Patients With (http://her2support.org/vbulletin/showthread.php?t=58709)

'lizbeth 07-29-2013 09:48 AM

Vaccine Therapy in Combination With Rintatolimod and/or Sargramostim in Patients With
 
Vaccine Therapy in Combination With Rintatolimod and/or Sargramostim in Patients With Stage II-IV HER2-Positive Breast Cancer



http://www.clinicaltrials.gov/ct2/sh...rm=her2&rank=5


This randomized phase I/II trial studies the side effects and best dose of rintatolimod when given together with vaccine therapy and sargramostim (GM-CSF) to see how well it works in treating patients with stage II-IV human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Vaccines made from synthetic HER2/neu peptides may help the body build an effective immune response to kill tumor cells that express HER-2/neu. Our group has developed vaccines against the HER2 protein that create immune responses and in this study we are researching different ways that we may be able to make that immune response even better. Adjuvants are one way to help vaccines produce stronger immune responses. Our group has typically used the adjuvant GM-CSF and in this study we would like to look at another adjuvant called rintatolimod. Giving vaccine therapy together with rintatolimod and/or GM-CSF may be an effective treatment for breast cancer.


rintatolimod is also known as Ampligen


http://www.hemispherx.net/content/rn...candidates.htm



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