Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

Hello,

Does anyone here on quad combination of Trastuzumab (Herceptin), Everolimus (Afinitor), Exemestane (Aromasin), and Pertuzumab (Perjeta)?

Many thanks,

Nguyen

Linda's treatment history:

02/2014 – Current: Everolimus (5mg), Exemestane, herceptin
08/2013 – 01/2014: Femara, herceptin
12/2012 – 07/2013: 4mg estradiol, herceptin
08/2012 - 12/2012: Fulvestran 500mg, exemestane, Herceptin (Stop everolimus due to mouthsores)
05/2012 - 08/2012: Everolimus (10mg), Exemestane, Herceptin, Zometa
08/2011 - 05/2012: Herceptin, Tykerb, Femara, Zometa
08/2010 - 08/2011: Herceptin, Femara, Zometa
09-2009 - 08/2010: Herceptin and estradiol (6mg)
09/2008 - 09/2009: Herceptin, Fulvestrant, Femara
03/2008 - 09/2008: Herceptin, Exemestane, Oophorectomy
01/2005 - 03/2008: Herceptin (readded) and Femara
07/2004: It returned again via several small nodules in the lung
10/2002: NED (via CT and CA27.29)!
10/2001 - 01/2005: Femara, (Fosamax)
12/2000 - 10/2001: Herceptin and Navelbine
12/2000: lung metastatic was diagnosed (a few small nodules)
02/1998 - 12/2000: Daily Tamoxifen
05/1997 - 04/1998: Modified Radical Mastectomy, many many cycles of chemo regiments (CAF,Taxol, Carpoplatin, Thiotepa, Navelbine, Taxotere), including HDC, and radiation
05/1997: First diagnosed with BC stage 3A, ER+, PR+, HER2 +, poorly differentiated, nuclear grade 3.

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

No experience on the 4 together, but I've been on Perjeta, Herceptin and Havalen for about 3 months now. Looks like the cancer has outsmarted those and I think this 4 drug combo will be my next step. I've been on aromasin before and not appreciated the joint pains. From everything I've read Everolimus is horrible- is that true? Any advice? Thanks and good luck.
Kristin

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

The first time at 10mg dosage my wife developed lots of unbearable mouth sores that we had to discontinue the treatment. This time around we are trying 5mg, so we'll see how it goes. Please see thread "remedies for mouth sores from everolimus" for info.

Nguyen

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

I took Everolimus (Afinitor), Exemestane (Aromasin) for six months and was lucky I didn't get any mouth sores.
I hope your wife can tolerate it this time around. And I hope this combination will help your wife. Praying for her improvement.
Joanne S

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

I'm starting the quad combo tomorrow. Right now I'm on aromasin (exemestane), perjeta, herceptin AND morphine ER for neuropathy and joint pain, starting affinitor at 5 mg tomorrow.

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

Hi Kristin,
OMG you sure have had more than your share of chemo and pills. I hope this combo works for you. Please keep us posted. You are in my prayers.
Huge Hugs, Joanne

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

Hi Kristin,
OMG you sure have had more than your share of chemo and pills. I hope this combo works for you. Please keep us posted. You are in my prayers.
Huge Hugs, Joanne

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

Hi Kristin,

Question? Why are you adding Everolimus to the combo?

My doctor decided against Everolimus he said the studies
done on this drug shows no improvement at all - at least not enough
to go through these mouth sores. If you developed them maybe it
will be a good idea to stop it. Ask you doctor if he's aware of the benefits of
this drug. I'm so fortunate, my doctor is the best in the world, so caring
and supportive of me and my decisions to change treatment plans.
He's my rock.

Glad to hear you are doing well with halaven, just had my first treatment
today along with perjeta. Keeping my fingers crossed.

Take care,

Adriana

Re: Trastuzumab, Everolimus, Exemestane, Pertuzumab
 

I'm not sure whether this is more widespread, but a friend of mine didn't do well on Everolimus. It caused severe shortness of breath, and other symptoms which I cannot recall at the moment. She also needed blood transfusions, and she had to stop taking it. I think this is a very rare side effect, but as her doc hadn't heard of it, they couldn't figure out what was wrong with her. So please, if you notice any side effects, talk to your doc and insist that s/he researches them. My friend said she could have died from the SE's.

But like I said, they are rare and I've heard good things about its efficacy.

Love

Jacqueline