Comparison, ACT + Herceptin, TC + Herceptin
 

Second interim analysis, BCIRG 006:

http://news.moneycentral.msn.com/pro...214&ID=6278883

Hey, didn't Dr. Salmon tell us last year that topaII gene positivity meant that you needed AC. Now the BIRG is saying that AC may not be needed for her2bc so they must mean her2bc that is also not topa II positive.

blocks
 

One building block at a time....

(It IS nice to know that there just might actually BE a complete set. And I hope it includes the triple negatives when they DO find it.)

topo ii?
 

The updated results of the trial using AC followed by TH vs TCH vs AC followed by T is showing that the 2 Herceptin arms are coming together and there is no statistical advantage of AC followed by TH over TCH (and the survival and recurrence rates are running the same in these 2 arms over no Herceptin).


I saw this presentation personally given and Dr. Slamon is rethinking this Top 2A association. Secondly, it is being rethought because there were 4 cases of AML in the AC arms and none in the TCH arms.

In this and various other papers, adriamycin may be meeting its end. Although it works well in Her2 cancers, the addition of Herceptin to less heart toxic regimes is working out well (less heart effects in the TCH arm too).

AC-TH or TCH?
 

I went to a medical onc on Tuesday and another one yesterday for another opinion. The one on Tuesday told me to do the AC-TH and the other said TCH. The onc yesterday showed me the study from BCIRG and that seems to be the better way to go. However, the onc from Tuesday doesn't believe there's enough evidence to support that TCH is better. I don't know if he's seen the study or not. I'm also not sure if I should have a Topo II test or not to help determine which way I should lean. The onc from Tuesday said that my chances of developing any heart issues is less than 1% but the study seems to indicate differently. Any opinions, comments, experiences, etc. would be helpful. Thanks!

what is topo II test? 5 years before I was diagnosed with IBC- it was discovered I had HLTV I or II antibodies in my blood (people with leukemia or cronic fatique syndrome have this) but I wasn't sick. - I wonder if this has any connection with Her2nu?
there's got to be some clues they will find that will help women prevent this!!!

HTLV question
 

Joy,

I was diagnosed in 2002 with HER2 positive IDC and DCIS. When my onc recommended chemo, I asked him if there would be any problem related to my prior history of possible HTLV I-II positivity, because some chemos can eventually cause leukemia and I wanted to know if being possibly HTLV positive might mean it would be more likely I might end up with leukemia.

The only reason the question of HTLV positivity came up for me at all was because at one point I had my blood tested for autologous blood donation for a surgery I had. I would guess that there could be others who never find out that they might be HTLV positive.

I do not know what the connections or problems might be for you and I.

-AlaskaAngel

Please Help!! AC vs TCH
 

5/1 diagnosed locally advanced bc, ER+, PR+, HER2+, onco is recommending 4x AC dose dense 8 weeks + HT for 12 weeks.

I am so concerned about heart toxicity between the A and H, and have seen the reports from San Antonio. I am truly questioning whether TCH might be just as effective without running that risk. I also think Herceptin might be an immediate need, esp. as ER+ can be resistant to chemo?

ALso read that Herceptin at 3 week schedule is probably as effective as every week. Opinions? Advice?

Also, would like to know side effects of AC + TH vs TCH. (outside of heart risk)

Is TCH sometimes done dose dense also?

I am also questioning if ovary removal b4 chemo would be a good pre-emptive move. (100% er+ and 95%pr+)


PLEASE help. WE've only a couple weeks to figure this out. (doing preliminary scans and such right now) I am knocking heads with the onco on this so far, but will bring my printouts to her. She says we "need to bring in the big guns" but what I"ve read of the newer research so far doesn't necessarily say that AC is better. (I know it used to be looked at that way till very recently)

Thank-you,

Terri

Profcollege@hotmail.com