I too have mets to my spine hips and ribs.I was diag. last year in Feb.I went on taxol/carboplaxin/cmf every 21 days and herceptin weekly.Also I do Aridia monthly for the bones.I went into remission for a short time last year but because the cancer is agressive it came back.I too am her2+.I then went on adrimycin for 4 treatments every 21 days and now I am on taxotere/herceptin every 21 days.I just had my 3rd treatment and my markers are now down to a 15 which is good. So you can get herceptin either way weekly or every 21 days. best wishes to a positive outcome.....LuAnn