Re: Update - progression confirmed; the last shoe drops
 

Hi Chris,
That news is the pits. Your options do sound good. It is the first one that I have been reading about. It surely makes good sense.
You've got my prayers for wisdom and quick success.
much luv, ma

Re: Update - progression confirmed; the last shoe drops
 

Hi Chrisy. I am so sorry you cannot continue with TDM1. Is the liver met always the same one and is it in a reachable place? If you can have it taken out by RFA or celio would they take you back on TDM1? I figure you already went through all this so forgive my stupid questions but my dream is to see you back on TDM1 again. Hugs. Michka

Re: Update - progression confirmed; the last shoe drops
 

Hi, Chrisy,
News of progression is always a let down, but it passes once you realize you ARE a soldier and you will bring out new guns! Steph took the words right out my mouth...you've got a closet full of options. I also had progression on the liver shortly after NED, and it was traumatic, but on the new regimen, Tykerb/Xeloda/Herceptin, I am nearly normal again after the first 1.5 cycles. You are going to be fine, I know it. Look at your history! You'll find the right combo again and it'll take for a nice, long ride...maybe into The Land of The Cure for HER2 or one of these great vaccines.
Love,
Karen

Re: Update - progression confirmed; the last shoe drops
 

Sending my prayers also.

Amelia

Re: Update - progression confirmed; the last shoe drops
 

So, crap on a crapstick. I think the universe is telling us it's time for you to chart NEW uncharted territory, as you are our pied piper...

Rich, you are correct about Abraxane picking up when Taxol fails. I know many Oncs who really really like it. Also, CT, have any docs mentioned Navelbine? I know it's supposed to be a good one for liver mets... (it's one that is still in our back pocket... too)

And, hows about everolimus (Afinitor) - it sounds interesting...
http://www.breastcancer.org/treatmen.../20100607b.jsp

Re: Update - progression confirmed; the last shoe drops
 

Chris,

You did get a long ride out of T-DM1, which is great. Now on to getting rid of that pesky met that keeps coming back in the same place, and now a node too.

I'm sure you'll come up with a good plan.

Joan

Re: Update - progression confirmed; the last shoe drops
 

Re: Update - progression confirmed; the last shoe drops
 

Chrisy, sorry to read of this development but am sure you will find a way to knock that node into submission.
Thinking of you.

Re: Update - progression confirmed; the last shoe drops
 

Chrisy,
Glad to hear from you....frustrated by the news that a liver met is indeed lurking.
Your medical team seems to be so open to different options, both old and new. (oh...and so are you) I agree with Brenda that you had good luck being on the leading edge with TDM-1, maybe they can select anotherrleading edge drug combo that will work wonders.

It must not seem this way, but it is good news that you have a met in a single location.

If you just need shrinkage for localized treatment, please speak to the Drs. about Abraxane. It was my 2nd treatment and was very tolerable. Hardly knew I was on chemo.

Localized treatment...wish I had more time to wager an opinion. Cryosurgery was freaky but very very doable. Think root canal. Up and about the next day. Lasted a year or so. Then there is the "gold standard", the resection. The good thing about an open resection is that the surgeon can actually see what is happening. They identified 2 nodes that the PET didn't reflect. Feels good to just get the cancer OUT...gone.

So many options my dear, I will be anxious to hear which horse you choose.

We will be here cheering you on!!

Lots of fighting power coming headed your way....Lori

Re: Update - progression confirmed; the last shoe drops
 

So sorry to hear the news, but what a great run you have had brave lady. Like the other wise women have said, there are options out there and I am confident you and your team will find the right one for you.
I hope you can find some peace and move forward on your journey.
Please let us know what you eventually decide on, and there are lots of hugs coming your way.
Emelie

Re: Update - progression confirmed; the last shoe drops
 

Re: Update - progression confirmed; the last shoe drops
 

Chrissy,

You know I do not have any knowledge on things, but I do want to share that I LOVED your "horcrux" treatment and George Constanza shrinkage lines! You missed your calling at stand up, Girlfriend. Witty in the face of treatment! How very like you, Chrissy.

Well, you already know I am truly bummed about your run on TDM-1 coming to a close. It was a good, long run, but as you said, never long enough. This newest trial does sound intriguing except for the dratted Taxol. I truly hated that crap. However if it does the trick, it is worth the suffering. I am hoping you will qualify and then at least you have the option to exercise if you wish.

Best and prayers.

Re: Update - progression confirmed; the last shoe drops
 

Chrisy,

I know you'll be on top of these decisions about the trial vs. the approved choices. I'm adding my good thoughts on that to all the rest.

But mostly, I'm surprised to see you (of all people) label this the "last shoe". Do you really feel that to be true? It's okay if you do, and if so -- can you tell us about that?

Or if not, (Imelda), can you tell us about that, too?

Love and good thoughts and prayers,

Debbie Laxague

Re: Update - progression confirmed; the last shoe drops
 

Chris,

Can you get a biopsy to get the tumor in the liver tested? According
to the abstract listed below, there are quite a few cases in which the ER, PR, and Her2 status changed in liver metastasis.

Should liver metastases of breast cancer be biopsied to improve treatment choice?

Curigliano G, Bagnardi V, Viale G, Fumagalli L, Rotmensz N, Aurilio G, Locatelli M, Pruneri G, Giudici S, Bellomi M, Della Vigna P, Monfardini L, Orsi F, Nolè F, Munzone E, Goldhirsch A.
Ann Oncol. 2011 Feb 22. [Epub ahead of print]

^^
Shall we put out a 'wanted' notice for 'George'? Love that 'shrinkage' reference.

Re: Update - progression confirmed; the last shoe drops
 

Hey Debbie, I will try and clarify for Chris, if I may be so bold.

I believe what she meant by "last shoe" was specific only to her involvement in the TDM1 trial. Little by little over the last couple of months her trial folks and doctor were trying to determine if she was truly having progression on TDM1. Slowly but surely it was revealed that what they were seeing was progression, not just a glitch of some sort... so the 'last shoe' was the final determination by all involved to throw in the towel on TDM1, that it had stopped working for her, and it was time to look elsewhere... (as well cancel travel plans for the summer, etc etc etc...)

I know she is bummed, but she is not down and out. She's on the confusing path to the next thing in the toolbox, but whether it's going to be a hammer, a wrench or a screwdriver is the question. Maybe all three!

Re: Update - progression confirmed; the last shoe drops
 

Re: Update - progression confirmed; the last shoe drops
 

Chrisy

Perhaps the met turned hormone positive and is screaming out for tamoxifen or something - just a thought.

On what chemo drug that is linked to TMD1 - it may have to do what they can chemically link to Herceptin without destroying Herceptin's properties (so that it rushes to Her2 receptors). It may also be catalyst dependent (to keep the chemical reaction's temperature low also to protect the Herceptin). I am sure the biochemists are thinking but the bonds they would have to use to join the 2 molecules would have to work out with each other and the chemical reaction has to be right to maintain the properties of each component (Herceptin to the Her2 receptor and that the chemo part also acts as chemo).

Re: Update - progression confirmed; the last shoe drops
 

http://www.newsday.com/news/health/f...cers-1.2956624

Just wanted to add this link, which was in New York's Newsday on 14 June. The FDA has approved a new test to identify HER-2 cancer, thereby eliminating lost time on a regimen if Herceptin will NOT work on a patient.
Karen

Re: Update - progression confirmed; the last shoe drops
 

Chrisy my internet connection has been troublesome all week so just getting to see your post now and was sorry to read the news.

However it's just one met and I know you'll handle it and agree with Steph, you have many more shoe's to drop !!!! xx

Re: Update - progression confirmed; the last shoe drops
 

Brenda, you spoke very well for me. I invite you to speak for me whenever you want!!!!!

Yes, the last shoe reference was to the long road to determining progression on TDM1, which actually started in December!

Sorry I have not posted any responses to anyone, I have been travelling around all week and only have my iphone which has it's own ideas about how to respond to keystrokes!

I am, as Brenda said, in the process of screening for this new study, one criteria I can check off is the LVEF which came back a nice strong 66. A few of the other criteria are dicey, and I'm waiting to hear back re the screening blood labs I had drawn yesterday.

I am planning to have a new liver biopsy - I think it was Becky it the nail on the head, my Dr. is wondering if maybe now there is some ER/PR positivity.

On the other point, research on linking a different chemo to herceptin, there is research ongoing on that question. I do remember speaking with the genentech researcher who developed TDM1 who told me they had experimented with many many different agents during TDM1 development - like everything else, it is always more complicated than we'd like.

Now that I am back on a real computer, I'll reread all the comments - lots of great things to think about, thank you!